Dr. Choi is a clinician-scientist with expertise in the pathology and biology of lung disease. His laboratory research has focused on stress response genes and antioxidant enzymes, in particular heme oxygenase-1 (HO-1) and gaseous molecule carbon monoxide (CO), in response to oxidative stress and inflammation in a variety of models of lung disease such as acute respiratory distress syndrome. His laboratory also focuses on the improved understanding of the pathogenesis of chronic obstructive pulmonary disease (COPD). Dr. Choi's research has recently focused on the role of autophagy in acute and chronic lung diseases and his laboratory is currently examining whether low-dose inhaled carbon monoxide can be an effective therapy in human disease. He is a principal investigator of 4 NIH R01 grants, a NIH Program Project Grant, and a NIH U0 grant.
Dr. Choi has authored more than 235 original publications in peer-reviewed journals, plus 16 book chapters and 60 reviews. He is a member of the American Society of Clinical Investigation and Association of American Physicians. Dr. Choi has served on numerous leadership positions for the American Thoracic Society, including chair of Respiratory and Cell and Molecular Biology Assembly and Scientific Program Committee, chair of the Research Advocacy Committee, and chair of the Task Force on Mentoring/Training. He was the recipient of the 2011 Ho-Am Prize in Medicine, awarded for outstanding contributions to the development of science and medicine, often referred to as the Korean Nobel Prize.After receiving his medical degree from University of Louisville, Dr. Choi served as an intern, resident and assistant chief resident in internal medicine at Duke University Medical Center. He then completed a fellowship in pulmonary and critical care medicine at Johns Hopkins University. Prior to joining Harvard and Brigham and Women's Hospital as chief of the Division of Pulmonary and Critical Care Medicine in 2007, Dr. Choi served on the faculty and medical staff of Johns Hopkins, Yale University and University of Pittsburgh, where he served as chief of pulmonary, allergy and critical care medicine.