Publications
Original research articles
1. Yin, F, Banerjee, R, Thomas, B, Zhou, P, Qian, L, Jia, T, Ma, X, Ma, Y, Iadecola, C, Beal, MF, Nathan, C and Ding, H. 2010. Exaggerated Inflammation, Impaired Host Defense and Neuropathology in Progranulin-Deficient Mice. J. Exp. Med. 207(1):117-128
2. Jiao, X., Katiyar, S., Willmarth, NE, Liu, M., Flomenberg, N., Ma, X., Lisanti, MP, Pestell, RG. 2010. C-jun induces mammary epithelial cellular invasion and breast cancer stem cell expansion. J. Biol. Chem. 285(11):8218-8226.
3. Kang, X, Kim, HJ, Ramirez, M, Salameh, S, Ma, X. 2010. The Septic Shock-associated IL-10 -1082 A>G Polymorphism Mediates Allele-specific Transcription via Poly ADP-ribose Polymerase 1 in Macrophages Engulfing Apoptotic Cells. J. Immunol. 184:3718-3724.
4. Zhang, Y. Ma, X. 2010. Triptolide Inhibits IL-12/IL-23 Gene Expression in Antigen-presenting Cells via CCAAT/enhancer-Binding Protein Alpha. J. Immunol. 184:3866-3877.
5. Eiichiro, N., Homma, Y., Kang, X., Netea, MG, and Ma, X. 2009. A Crohn’s disease–associated NOD2 mutation suppresses transcription of human IL10 by inhibiting activity of the nuclear ribonucleoprotein hnRNP-A1. Nature Immunology. 10(5):471-479.
6. Leavenworth JW, Ma X, Mo YY, Pauza ME. SUMO conjugation contributes to immune deviation in nonobese diabetic mice by suppressing c-Maf transactivation of IL-4. 2009.J Immunol. 2009 Jul 15;183(2):1110-1119.
7. Yamamoto, S., Ma, X. 2009. Role of Nod2 in the development of Crohn’s disease. Microbes and Infection. 11(12):912-918.
8. Jayakumar, A., Widenmaier, R., Ma, X., and McDowell, MA. 2008. Transcriptional inhibition of interleukin-12 promoter activity in leishmania spp.-infected macrophages. J. Parasitol., 94(1):84–93.
9. Chung, E., Liu, J., Homa, Y., Zhang,Y., Brendolan, A., Saggese, M., Han, J., Silverstein, R., Selleri, L., X.Ma. 2007. Interleukin-10 Expression in Macrophages during Phagocytosis of Apoptotic Cells Is Mediated by the TALE homeoproteins Pbx-1 and Prep-1. Immunity. 27:952-964.
10. Liu, J., Guan, X., X. Ma. 2007. Regulation of IL-27 p28 gene expression in macrophages through MyD88- and Interferon-g-mediated pathways. J Exp Med. 204:141-152.
11. Park-Min, K., Serbina, N., Yang, W., X. Ma, Krystal, G., Neel, BJ, Nutt, SL, Hu, X., and Ivashkiv, LB. 2007. FcγRIII-Dependent Inhibition of Interferon-γ Responses Mediates Suppressive Effects of Intravenous Immune Globulin. Immunity. 26, 67-78.
12. Chung, EY, Liu, J., Zhang, Y., and X. Ma. 2007. Differential Expression in Lupus-associated IL-10 Promoter Single-nucleotide Polymorphisms Is Mediated by Poly(ADP-ribose) Polymerase 1. Genes & Immunity. 8(7):577-589.
13. Homma, Y., Cao, S., Shi, X., and X. Ma. 2007. The Th2 transcription factor c-Maf inhibits IL-12p35 gene expression in activated macrophages by targeting NF-kB nuclear translocation. J. Interferon & Cytokine Res. 27(9):799-808.
14. Werts, C., le Bourhis, L., Liu, J., Magalhaes, JG., Fritz, JH., Stockinger, S., Decker, T., Philpott, DJ., Ma, X., and Girardin. SE. 2007. Nod1 and Nod2 induce CCL5/RANTES through the NF-κB pathway. Eur. J. Immunol. 37(9):2499-2508.
15. Murray, H.W., C.W. Tsai, J. Liu, and X. Ma. 2006. Responses to Leishmania donovani in Mice Deficient in Interleukin-12 (IL-12), IL-12/IL-23, or IL-18. Infect Immun 74:4370-4374.
16. Murray, H.W., Z. Xiang, and X. Ma. 2006. Responses to Leishmania donovani in mice deficient in both phagocyte oxidase and inducible nitric oxide synthase. Am J Trop Med Hyg 74:1013-1015.
17. Murray, H.W., C.W. Tsai, J. Liu, and X. Ma. 2006. Visceral Leishmania donovani Infection in Interleukin-13-/- Mice. Infect Immun 74:2487-2490.
18. Liu, J., and X. Ma. 2006. Interferon regulatory factor 8 regulates rantes gene transcription in cooperation with interferon regulatory factor-1, NF-kappa B and PU.1. J Biol Chem 281:19188-19195.
19. Liu, J., Mankani, G., Shi, X., Meyer, M., Cunningham-Runddles, S., Ma, X., Sun, Z. 2006. The Circadian Clock Period 2 Gene Regulates IFN-gamma production of NK Cells in Host Response to LPS-induced Endotoxic Shock. Infect Immun 74:4750-4756.
20. Wu, Y., Z. Liu, Z. Xiang, C. Zeng, Z. Chen, X. Ma, and L. Li. 2006. Obesity-related glomerulopathy: insights from gene expression profiles of the glomeruli derived from renal biopsy samples. Endocrinology 147:44-50.
21. Tripathi, P., R. Madan, C. Chougnet, S. Divanovic, X. Ma, L.M. Wahl, T. Gajewski, C.L. Karp, and D.A. Hildeman. 2006. An adenoviral vector for probing promoter activity in primary immune cells. J Immunol Methods 311:19-30.
22. Torroella-Kouri, M., Ma, X., Perry, G., Ivanova, M., Cejas, P.J., Owen, J.L., Iragavarapu-Charyulu, V. Lopez, D.M. 2005. Diminished expression of transcription factors NFkB and C/EBP underlie a novel tumor evasion mechanism affecting macrophages of mammary tumor-bearing mice. Cancer Research 65:10578-10584.
23. Shan, D., L. Chen, J.T. Njardarson, C. Gaul, X. Ma, S.J. Danishefsky, and X.Y. Huang. 2005. Synthetic analogues of migrastatin that inhibit mammary tumor metastasis in mice. Proc Natl Acad Sci U S A 102:3772-3776.
24. Murray, H.W., K.C. Flanders, D.D. Donaldson, J.P. Sypek, P.J. Gotwals, J. Liu, and X. Ma. 2005. Antagonizing deactivating cytokines to enhance host defense and chemotherapy in experimental visceral leishmaniasis. Infect Immun 73:3903-3911.
25. Liu, J., X. Guan, and X. Ma. 2005. Interferon regulatory factor 1 is an essential and direct transcriptional activator for interferon {gamma}-induced RANTES/CCl5 expression in macrophages. J Biol Chem 280:24347-24355.
26. Cao, S., J. Liu, L. Song, and X. Ma. 2005. The Protooncogene c-Maf Is an Essential Transcription Factor for IL-10 Gene Expression in Macrophages. J Immunol 174:3484-3492.
27. Shi, X., S. Cao, M. Mitsuhashi, Z. Xiang, and X. Ma. 2004. Genome-wide analysis of molecular changes in IL-12-induced control of mammary carcinoma via IFN-gamma-independent mechanisms. J Immunol 172:4111-4122.
28. Shi, X., J. Liu, Z. Xiang, M. Mitsuhashi, R.S. Wu, and X. Ma. 2004. Gene expression analysis in Interleukin-12-induced suppression of mouse mammary carcinoma. Int J Cancer 110:570-578.
29. Mitsuhashi, M., J. Liu, S. Cao, X. Shi, and X. Ma. 2004. Regulation of interleukin-12 gene expression and its anti-tumor activities by prostaglandin E2 derived from mammary carcinomas. J Leukoc Biol 76:322-332.
30. Luo, Q., X. Ma, S.M. Wahl, J.J. Bieker, M. Crossley, and L.J. Montaner. 2004. Activation and repression of interleukin-12 p40 transcription by erythroid Kruppel-like factor in macrophages. J Biol Chem 279:18451-18456.
31. Liu, J., X. Guan, T. Tamura, K. Ozato, and X. Ma. 2004. Synergistic Activation of Interleukin-12 p35 Gene Transcription by Interferon Regulatory Factor-1 and Interferon Consensus Sequence-binding Protein. J Biol Chem 279:55609-55617.
32. Liu, J., Z. Xiang, and X. Ma. 2004. Role of IFN regulatory factor-1 and IL-12 in immunological resistance to pathogenesis of N-methyl-N-nitrosourea-induced T lymphoma. J Immunol 173:1184-1193.
33. Kim, S., K.B. Elkon, and X. Ma. 2004. Transcriptional suppression of interleukin-12 gene expression following phagocytosis of apoptotic cells. Immunity 21:643-653.
34. Cao, S., Xiang, Z., and Ma, X. 2004. Global Gene Expression Profiling in Interleukin-12-induced Activation of CD8 Cytotoxic T Lymphocytes against Mouse Mammary Carcinoma. Cellular and Molecular Immunology 1:357-366.
35. Xiang, Z., Y. Yang, X. Ma, and W. Ding. 2003. Microarray expression profiling: analysis and applications. Curr Opin Drug Discov Devel 6:384-395.
36. Murray, H.W., A.L. Moreira, C.M. Lu, J.L. DeVecchio, M. Matsuhashi, X. Ma, and F.P. Heinzel. 2003. Determinants of response to interleukin-10 receptor blockade immunotherapy in experimental visceral leishmaniasis. J Infect Dis 188:458-464.
37. Liu, J., S. Cao, L.M. Herman, and X. Ma. 2003. Differential regulation of interleukin (IL)-12 p35 and p40 gene expression and interferon (IFN)-gamma-primed IL-12 production by IFN regulatory factor 1. J Exp Med 198:1265-1276.
38. Kim, S.J., D. Gershov, X. Ma, N. Brot, and K.B. Elkon. 2002. I-PLA(2) activation during apoptosis promotes the exposure of membrane lysophosphatidylcholine leading to binding by natural immunoglobulin M antibodies and complement activation. J Exp Med 196:655-665.
39. Cao, S., J. Liu, M. Chesi, P.L. Bergsagel, I.C. Ho, R.P. Donnelly, and X. Ma. 2002. Differential regulation of IL-12 and IL-10 gene expression in macrophages by the basic leucine zipper transcription factor c-Maf fibrosarcoma. J Immunol 169:5715-5725.
40. Grazia Cappiello, M., F.S. Sutterwala, G. Trinchieri, D.M. Mosser, and X. Ma. 2001. Suppression of Il-12 transcription in macrophages following Fc gamma receptor ligation. J Immunol 166:4498-4506.
41. Byrnes, A.A., X. Ma, P. Cuomo, K. Park, L. Wahl, S.F. Wolf, H. Zhou, G. Trinchieri, and C.L. Karp. 2001. Type I interferons and IL-12: convergence and cross-regulation among mediators of cellular immunity. Eur J Immunol 31:2026-2034.
42. Becker, C., S. Wirtz, X. Ma, M. Blessing, P.R. Galle, and M.F. Neurath. 2001. Regulation of IL-12 p40 promoter activity in primary human monocytes: roles of NF-kappaB, CCAAT/enhancer-binding protein beta, and PU.1 and identification of a novel repressor element (GA-12) that responds to IL-4 and prostaglandin E(2). J Immunol 167:2608-2618.
43. Wang, I.M., C. Contursi, A. Masumi, X. Ma, G. Trinchieri, and K. Ozato. 2000. An IFN-gamma-inducible transcription factor, IFN consensus sequence binding protein (ICSBP), stimulates IL-12 p40 expression in macrophages. J Immunol 165:271-279.
44. Ma, X., J. Sun, E. Papasavvas, H. Riemann, S. Robertson, J. Marshall, R.T. Bailer, A. Moore, R.P. Donnelly, G. Trinchieri, and L.J. Montaner. 2000. Inhibition of IL-12 production in human monocyte-derived macrophages by TNF. J Immunol 164:1722-1729.
45. Pardoux, C., X. Ma, S. Gobert, S. Pellegrini, P. Mayeux, F. Gay, G. Trinchieri, and S. Chouaib. 1999. Downregulation of interleukin-12 (IL-12) responsiveness in human T cells by transforming growth factor-beta: relationship with IL-12 signaling. Blood 93:1448-1455.
46. Na, S.Y., B.Y. Kang, S.W. Chung, S.J. Han, X. Ma, G. Trinchieri, S.Y. Im, J.W. Lee, and T.S. Kim. 1999. Retinoids inhibit interleukin-12 production in macrophages through physical associations of retinoid X receptor and NFkappaB. J Biol Chem 274:7674-7680.
47. Ma, X., H. Riemann, G. Gri, and G. Trinchieri. 1998. Positive and negative regulation of interleukin-12 gene expression. Eur Cytokine Netw 9:54-64.
48. Karp, C.L., M. Wysocka, X. Ma, M. Marovich, R.E. Factor, T. Nutman, M. Armant, L. Wahl, P. Cuomo, and G. Trinchieri. 1998. Potent suppression of IL-12 production from monocytes and dendritic cells during endotoxin tolerance. Eur J Immunol 28:3128-3136.
49. Gri, G., D. Savio, G. Trinchieri, and X. Ma. 1998. Synergistic regulation of the human interleukin-12 p40 promoter by NFkappaB and Ets transcription factors in Epstein-Barr virus-transformed B cells and macrophages. J Biol Chem 273:6431-6438.
50. Coughlin, C.M., K.E. Salhany, M.S. Gee, D.C. LaTemple, S. Kotenko, X. Ma, G. Gri, M. Wysocka, J.E. Kim, L. Liu, F. Liao, J.M. Farber, S. Pestka, G. Trinchieri, and W.M. Lee. 1998. Tumor cell responses to IFNgamma affect tumorigenicity and response to IL-12 therapy and antiangiogenesis. Immunity 9:25-34.
51. Aste-Amezaga, M., X. Ma, A. Sartori, and G. Trinchieri. 1998. Molecular mechanisms of the induction of IL-12 and its inhibition by IL-10. J Immunol 160:5936-5944.
52. Sartori, A., X. Ma, G. Gri, L. Showe, D. Benjamin, and G. Trinchieri. 1997. Interleukin-12: an immunoregulatory cytokine produced by B cells and antigen-presenting cells. Methods 11:116-127.
53. Moller, D.R., M. Wysocka, B.M. Greenlee, X. Ma, L. Wahl, G. Trinchieri, and C.L. Karp. 1997. Inhibition of human interleukin-12 production by pentoxifylline. Immunology 91:197-203.
54. Moller, D.R., M. Wysocka, B.M. Greenlee, X. Ma, L. Wahl, D.A. Flockhart, G. Trinchieri, and C.L. Karp. 1997. Inhibition of IL-12 production by thalidomide. J Immunol 159:5157-5161.
55. Ma, X., M. Neurath, G. Gri, and G. Trinchieri. 1997. Identification and characterization of a novel Ets-2-related nuclear complex implicated in the activation of the human interleukin-12 p40 gene promoter. J Biol Chem 272:10389-10395.
56. Ma, X., M. Aste-Amezaga, G. Gri, F. Gerosa, and G. Trinchieri. 1997. Immunomodulatory functions and molecular regulation of IL-12. Chem Immunol 68:1-22.
57. Ma, X., J.M. Chow, G. Gri, G. Carra, F. Gerosa, S.F. Wolf, R. Dzialo, and G. Trinchieri. 1996. The interleukin 12 p40 gene promoter is primed by interferon gamma in monocytic cells. J Exp Med 183:147-157.
58. Ma X, Aste-Amezaga M Trinchieri G. Regulation of interleukin-12 production. Ann N Y Acad Sci 1996; 795: 13-25.
59. Ma X, Gri G Trinchieri G. A novel ets-2-related nuclear factor is involved in transcriptional activation of the human interleukin-12 p40 gene promoter in response to interferon-gamma and LPS stimulation of monocytic cells. Ann N Y Acad Sci 1996; 795: 357-60.
60. Chehimi J, Ma X, Chouaib S, Zyad A, Nagashunmugam T, Wojcik L, Chehimi S, Nissim L Frank I. Differential production of interleukin 10 during human immunodeficiency virus infection. AIDS Res Hum Retroviruses 1996; 12: 1141-9.
61. Aste-Amezaga M, Ma X Trinchieri G. Regulation by interleukin-10 of Staphylococcus aureus- and lipopolysaccharide-induced interleukin-12 gene expression in human peripheral blood mononuclear cells. Ann N Y Acad Sci 1996; 795: 319-20.
62. Ma X, D'Andrea A, Kubin M, Aste-Amezaga M, Sartori A, Monteiro J, Showe L, Wysocka M Trinchieri G. Production of interleukin-12. Res Immunol 1995; 146: 432-8.
63. D'Andrea A, Ma X, Aste-Amezaga M, Paganin C Trinchieri G. Stimulatory and inhibitory effects of interleukin (IL)-4 and IL-13 on the production of cytokines by human peripheral blood mononuclear cells: priming for IL-12 and tumor necrosis factor alpha production. J Exp Med 1995; 181: 537-46.
64. Cassatella MA, Meda L, Gasperini S, D'Andrea A, Ma X Trinchieri G. Interleukin-12 production by human polymorphonuclear leukocytes. Eur J Immunol 1995; 25: 1-5.
65. Chehimi J, Starr SE, Frank I, D'Andrea A, Ma X, MacGregor RR, Sennelier J Trinchieri G. Impaired interleukin 12 production in human immunodeficiency virus-infected patients. J Exp Med 1994; 179: 1361-6.
66. Ma X, Saitoh N Curtis PJ. Purification and characterization of a nuclear DNA-binding factor complex containing topoisomerase II and chromosome scaffold protein 2. J Biol Chem 1993; 268: 6182-8.
67. D'Andrea A, Aste-Amezaga M, Valiante NM, Ma X, Kubin M Trinchieri G. Interleukin 10 (IL-10) inhibits human lymphocyte interferon gamma-production by suppressing natural killer cell stimulatory factor/IL-12 synthesis in accessory cells. J Exp Med 1993; 178: 1041-8.
68. Ma X, Fraser P Curtis PJ. A differentiation stage-specific factor interacts with mouse carbonic anhydrase form I gene and a conserved sequence in mammalian beta-globin genes. Differentiation 1991; 47: 135-41.
69. Clark AJ, Chave-Cox A, Ma X. Bishop JO. Analysis of mouse major urinary protein genes: variation between the exonic sequences of group 1 genes and a comparison with an active gene out with group 1 both suggest that gene conversion has occurred between MUP genes. EMBO J 1985; 4: 3167-71.
Books, Book Chapters and Reviews
1. Zhang, Y, Kim, HJ, Yamamoto, S, Kang, X, Ma, X. 2010. Regulation of IL-10 Gene Expression in Macrophages Engulfing Apoptotic Cells. J. Interferon & Cytokine Res.(E-publication online February 28)
2. Yamamoto, S., Ma, X. 2009. Role of Nod2 in the development of Crohn’s disease. Microbes and Infection. 11(12):912-918.
3. Chung, E.Y., S.J. Kim, and X.J. Ma. 2006. Regulation of cytokine production during phagocytosis of apoptotic cells. Cell Res 16:154-161.
4. Liu, J., Cao, S., Kim, S.J., Chung, E.Y., Homma, Y., Jimenez, V., Ma, X. 2005. Interleukin-12: an update on its immunological activities, signaling and regulation of gene expression. Current Immunology Reviews 1:119-137.
5. Kim, S., E.Y. Chung, and X. Ma. 2005. Immunological Consequences of Macrophage-Mediated Clearance of Apoptotic Cells. Cell Cycle 4:231-234.
6. Kim, S.J., Gershov, D., Ma, X., Brot, N., Elkon, E.L. 2003. Opsonization of Apoptotic Cells and its Effect on Macrophage and T cell Immune Responses. Ann N Y Acad Sci. 987:68-78.
7. Xiang, Z., Yang, Y., Ma, X., and Ding, W. 2003. Microarray Expression Profiling: Analysis and Applications. Current Opinions in Drug Discovery and Development 6(3):384-395.
8. Ma, X. 2001. TNF-a and IL-12: a balancing act in macrophage functioning. Microbes and Infection. Forum in Immunology: inhibitory receptors of mononuclear phagocytes. Institut Pasteur. 3(2):121-9.
9. Ma. X. and Trinchieri G. 2001. Regulation of Interleukin-12 production in antigen-presenting cells. Advances in Immunology. 79:55-92.
10. Ma. X. and Montaner, L.J. 2000. HIV-1 infection: proinflammatory response and IL-12 production by macrophages. J Leukoc Biol. 68(3):383-90.
11. Ma, X., Reimann, H., Gri, G., and Trinchieri, G. 1998. Positive and negative regulation of Interleukin-12 gene expression. Eur Cytokine Netw. 9(3 Suppl):54-64.
12. Neurath, M., Ma, X., and Pettersson, S. (262 pages). 1997. DNA-protein interactions. Spectrum Akadenvischer Verlag, Heidelberg, Berlin, Oxford.
13. Ma X.,Aste-Amezaga M, Gri G, Gerosa F, Trinchieri G. 1997. Immunomodulatory functions and molecular regulation of IL-12. Chem Immunol. 68:1-22.
