Publications
Selected Publications
Ding BS, Nolan DJ, Guo P, Babazadeh AO, Cao Z, Rosenwaks Z, Crystal RG, Simons M, Sato TN, Worgall S, Shido K, Rabbany SY, Rafii S. Endothelial-Derived Angiocrine Signals Induce and Sustain Regenerative Lung Alveolarization. Advanced On-line publication: DOI 10.1016/j.cell.2011.10.003.
Kobayashi H, Butler J, O'Donnell R, Kobayashi M, Ding B, Bonner B, Chiu VK, Nolan DJ, Shido K, Benjamin L, Rafii S. Angiocrine factors derived from Akt-activated endothelium balance self-renewal and differentiation of hematopoietic stem cells. Nature Cell Biology. 11:1046-56, 2010.
Ding BS, Nolan DJ, Butler JM, James D, Babazadeh A, Rosenwaks Z, Mittal V, Kobayashi H, Shido K, Lyden D, Sato TN, Rabbany SY, Rafii S. Inductive signals from sinusoidal endothelial cells initiate and sustain physiological liver regeneration. Nature. 468(7321):310-5, 2010.
Butler JM, Nolan D, Vertes E, Varnum-Finney B, Hooper AT, Kobayashi H, White I, Shido K, Zhu Z, Witte L, Shawber C, Kimura Y, Kitajewski J, Bernstein I, and Rafii S. Endothelial cells are essential for the self-renewal and repopulation of Notch-dependent hematopoietic stem cells. Cell Stem Cell, 6(3):251-64.2010.
James D, Nam HS, Seandel M, Nolan D, Janovitz T, Studer L, Lee G, Lyden D, Benezra R, Zaninovic N, Rosenwaks Z, Rabbany S and Rafii S. Expansion and maintenance of human embryonic stem cell–derived endothelial cells by TGFb inhibition is Id1 dependent. Nature Biotechnology, 28(2):161-6 2010.
Shmelkov SS, Hormigo A, Jing D, Proenca C, Bath KV, Shmelkov E, Kushner J, Dincheva I, Murphy AJ, Gale NW, Yancopoulos GD, Ninan I, Lee F, and Rafii S. Slitrk5 deficiency impairs cortical-striatal circuitry and leads to OCD-like behaviors in mice. Nature Medicine, Published online April 25, 2010.
Butler JM, Kobayashi H, and Rafii S. Instructive role of the vascular niche in promoting tumour growth and tissue repair by angiocrine factors. Nature Reviews Cancer, 10(2):138-46, 2010.
Hooper AT, Butler JM, Nolan DJ, Kobayashi M, Kranz, A, Shido K, Petit I, Yanger K, Avecilla S, Kopp H, James D, Witte L, Zhu Z, Pytowski B, Rosenwaks Z, Mittal V, Sato TN and Rafii S. Engraftment and reconstitution of hematopoiesis is dependent on VEGFR2-mediated regeneration of sinusoidal endothelial cells. Cell Stem Cell, 4:263-74, 2009.
Hooper AT, Shmelkov SV, Gupta S, Milde T, Bambino K, Gillen K, Goetz M, Chavala S, Baljevic M, Murphy AJ, Valenzuela DM, Thurston G, Yancopoulos GD, Vahdat L, Evans T, and Rafii S. Angiomodulin is a specific marker of vasculature and regulates vascular endothelial growth factor-A-dependent neoangiogenesis. Circulation Research. 105:201-8. 2009.
Seandel M, Butler J, Hooper AT, Zhang F, Shmelkov S, Rabbany S, Boyer J, and Rafii S. Generation of a functional and durable vascular niche by adenoviral E4ORF1 gene, PNAS, 105, 19288-93 2008.
Kim J, Seandel M, Falciatori I, Wen D, and Rafii S. CD34 Testicular Stromal Cells Support Long-Term Expansion of Embryonic and Adult Stem and Progenitor Cells. Stem Cells, 10:2516-22, 2008.
Swendeman S, Mendelson K, Weskamp G, Horiuchi K, Deutsch U, Scherle P, Hooper A, and Rafii S, Blobel CP. VEGF-A Stimulates ADAM17-Dependent Shedding of VEGFR2 and Crosstalk Between VEGFR2 and ERK Signaling, Circulation Research, 103:916-8, 2008.
Nachman R. and Rafii S. Platelet-Endothelial Cell Communications. New England Journal Of Medicine, 359:1261-70, 2008.
Shmelkov S, Butler J, Hooper A, Hormigo A, Kushner J, Baljevic M, White I, Murphy J, Gale NW, Thurston G, Yancopoulos GD, D'Angelica M, Kemeny N, Lyden D, and Rafii S. CD133 expression is not restricted to stem cells and both CD133 and CD133(-) cells initiate metastatic colon carcinomas. Journal of Clinical Investigation, 118:2111-20, 2008.
Petit I, Karajannis MA, Vincent L, Hooper AT, Shido K, Steller H, Chaplin DJ, Feldman E, and Rafii S. The microtubule targeting agent, CA4P, regresses leukemic xenografts by disrupting interaction with vascular cells and mitochondrial-dependent cell death. BLOOD, 15:1951-61, 2008.
Seandel M, James D, Shmelkov S, Falciatori I, Kim J, Chaval S, Torres R, Gale NW, Yancopoulos GD, Murphy A, Hobbs R, Pandolfi PP, and Rafii S. Generation of functional Multipotent adult spermatogonial-derived stem cells from GPR125 germline progenitors. Nature, 449:346-50, 2007.
Milde T, Shmelkov SV, Jensen KK, Zlotchenko G, Petit I, Rafii S. A novel family of slitrk genes is expressed on hematopoietic stem cells and leukemias. Leukemia, 21:824-7, 2007.
Kopp HG, Hooper AT, Broekman MJ, Avecilla ST, Luo M, Milde M, Ramos CA, Zhang F, Kopp T, Bornstein P, Lawler J, Marcus AJ, and Rafii S. Thrombospondins deployed by thrombopoietic cells determine angiogenic switch and extent of revascularization. Journal of Clinical Investigation, 116:3277-91, 2006.
Jin DK, Shido K, Kopp HG, Petit I, Shmelkov SV, Young LM, Hooper AT, Amano H, Avecilla ST, Heissig H, Hattori K, Zhang F, Hicklin DJ, Zhu Z, Dunn A, Salari H, Werb Z, Hackett NR, Crystal RG, Lyden D, and Rafii S. Cytokine-mediated deployment of SDF-1 induces revascularization through recruitment of CXCR4( ) hemangiocytes. Nature Medicine, 12:557-567, 2006.
Kaplan RN, Rebecca DR, Zacharoulis S, Jin DK, Bramley AB, Shido K, Kerns SA, Jensen KK, Shmelkov S, Port JL, Altorki N, Rafii S and Lyden D. VEGFR1 hematopoietic bone marrow progenitors initiate the premetastatic niche, Nature, 438:820-7, 2005. (Rafii S, is co-senior author).
Kopp HG, Avecilla ST, Hooper A., and Rafii S. Tie-2 activation contributes to hemangiogenic regeneration after myelosuppression. BLOOD, 106(2):505-13, 2005.
Vincent L, Jin DK, Shido K, Karajannis MA, Hicklin D., Hooper AT, Ely S, Niesvizky R, Chen-Kiang S, and Rafii S. Fetal stromal-dependent paracrine and intracrine VEGF-A/VEGFR-1 signaling promotes proliferation and migration of human primary myeloma cells. Cancer Research, 65:3185-92, 2005.
Avecilla ST, Hattori K, Heissig B, Tejada R, Liao F, Shido K, Jin DK, Zhang F, Hackett NR, Crystal RG, Witte L, Hicklin DJ, Bohlen P, Eaton D, Lyden D, Sauvage FD and Rafii S. Chemokine-Mediated Interaction of Hematopoietic Progenitors With The Bone Marrow's Vascular Niche Is Required For Thrombopoiesis. Nature Medicine, 10:64-71, 2004.
Zhang F, Cheng J, Hackett NR, Lam G, Shido K, Pergolizzi R, Jin DK, Crystal RG, and Rafii S. Adenovirus E4 gene promotes selective endothelial cell survival and angiogenesis via activation of the VE-cadherin/Akt signaling pathway. Journal of Biological Chemistry, 279:11760-6, 2004.
Shmelkov SV, St Clair R, McGarrigle D, Zhang F, and Rafii S. Alternative promoters regulate transcription of the gene encoding stem cell surface protein AC133 (CD133). BLOOD, 103:2055-61, 2004.
Heissig B, Hattori K, Dias S, Lyden D, Crystal RG, Moore MAS, Werb Z, and Rafii S. Recruitment of Stem and Progenitor Cells from the Bone Marrow Niche Requires MMP-9 Mediated Release of Kit-ligand. Cell, 109:625-637, 2002.
Hattori K, Heissig B, Wu Y, Dias S, Hicklin DJ, Bohlen P, Witte L, Hendrikx J, Hackett NR, Crystal RG, Moore MA, Werb Z, Lyden D, and Rafii S. Placental growth factor reconstitutes hematopoiesis by recruiting VEGFR1( ) stem cells from bone-marrow microenvironment. Nature Medicine, 8:841-849, 2002.
Lyden D. Hattori K., Dias S., Witte L., Hackett N. Crystal, RG, Hajjar K., Benezra R. and Rafii S. Impaired recruitment of bone marrow derived endothelial and hematopoietic precursor cells blocks tumor angiogenesis and growth. Nature Medicine, 7:1194-1201, 2001.
Hattori K, Dias S, Heissig B, Crystal RG, Moore MAS, and Rafii S. VEGF and Angiopoietin-1 stimulate hematopoiesis and promote extramedullary mobilization of endothelial and hematopoietic progenitor and stem cells, Journal of Experimental Medicine, 193:1005-14, 2001.
Dias S, Hattori K, Heissig B, Witte L, Moore MAS, and Rafii S. Inhibition of both paracrine and autocrine VEGF/VEGFR-2 signaling pathways is essential to induce long-term remission of xenotransplanted human leukemias, Proceedings National Academy of Sciences, 98:10857-62, 2001.
Gill MT, Dias S, Hattori K, Yurt R, and Rafii S. Vascular Trauma Induces Rapid but Transient Mobilization of VEGFR2 AC133 Endothelial Precursor Cells. Circulation Research, 88:167-174, 2001.
Dias S, Hattori K, Zhu Z, Chadburn A, Hyjek E, Hicklin J, Witte L, Moore MAS, and Rafii S. Autocrine stimulation of VEGFR-2 activates human leukemic cell growth and migration. JCI, 106:511-521, 2000.
Hamada T, Mohle R, Hoxie J, Moore MAS, and Rafii S. Transendothelial migration of megakaryocytes in response to SDF-1 enhances platelet formation, Journal of Exp Medicine, 188:539-48, 1998.
Frey BM, Crystal RG, Moore MAS, and Rafii S. High Efficiency Gene Transfer Into Ex Vivo Expanded Human Hematopoietic Progenitors Cells by Adenovirus Vectors. BLOOD, 91, 2781-2792, 1998.
Mohle R, Green D, Moore MAS, Nachman RL, and Rafii S. Constitutive production and thrombin induced release of vascular endothelial growth factor (VEGF) by human megakaryocytes and platelets. Proceedings National Academy of Sciences, 94:663-8, 1997.
