Roberto Levi, M.D.

• Research
• Honors & Awards
• Biography
• Publications

Publications

• Chan, N.Y-K., Seyedi, N.; Takano, K and Levi, R. An Unsuspected Property of Natriuretic Peptides: Promotion of Calcium-Dependent Catecholamine Release via PKG-Mediated PDE3 Inhibition. Circulation, 125: 298-307, 2012.
• Hashikawa-Hobara, N., Chan, N.Y.-K. and Levi, R. Histamine H₃-receptor activation reduces the expression of neuronal angiotensin AT₁-receptors in the heart. J. Pharmacol. Exp. Ther., 340: 185-191, 2012.
• Reid, A.C., Brazen, J.A., Morrey, C., Silver, R.B. and Levi, R.: Targeting cardiac mast cells: Pharmacological modulation of the local renin-angiotensin system. Curr. Pharmac. Design, 17: 3744-3752, 2011.
• Corti, F., Olson, K.E., Marcus, A.J. and Levi, R. The expression level of E-NTPDase1/CD39 modulates exocytotic and ischemic release of neurotransmitters in a cellular model of sympathetic neurons. J. Pharmacol. Exp. Ther., 337: 524-532, 2011.
• Silver RB, Reid AC, Brazin JA and Levi R.: Mast cells, local renin-angiotensin system and cardiovascular disease, in Mast Cells and Cardiovascular Disease (Joseph J. ed.), Nova Science Publishers, Inc., New York, 2010, pp 5-32.
• Morrey, C., Brazin, J., Seyedi, N., Corti, F., Silver, R.B. and Levi, R. Interaction between Sensory C-fibers and Cardiac Mast Cells in Ischemia/Reperfusion: Activation of a Local Renin-Angiotensin System Culminating in Severe Arrhythmic Dysfunction. J. Pharmacol. Exp. Ther., 335: 76-84, 2010.
• Koda, K., Salazar-Rodriguez, M., Corti, F., Chan, N.Y-K., Estephan, R., Silver, R.B., Mochly-Rosen, D. and Levi, R. Aldehyde dehydrogenase activation prevents reperfusion arrhythmias by inhibiting local renin release from cardiac mast cells. Circulation, 122: 771-781, 2010.
• Kano, S., Tyler, E., Salazar-Rodriguez, M., Estephan, R., Mackins, C.J., Veerappan, A., Reid, A.C., Silver, R.B. and Levi, R.: Immediate hypersensitivity elicits renin release from cardiac mast cells. Intl. Arch. Allergy Immunol., 146: 71-75, 2008.
• Morrey, C., Estephan, R., Abbott, G.W. and Levi, R. Cardioprotective Effect of histamine H₃-receptor activation: pivotal role of Gbg-dependent inhibition of voltage-operated Ca²⁺ channels. J. Pharmacol. Exp. Ther., 326: 871-878, 2008.
• Veerappan A, Reid AC, Estephan R, O'Connor N, Thadani-Mulero M, Salazar-Rodriguez M, Levi R, Silver RB. #147;Mast cell renin and a local renin-angiotensin system in the airway: role in bronchoconstriction.#148; Proc Natl Acad Sci U S A. 2008 Jan 29;105(4):1315-20.
• Machida T, Hamaya Y, Izumi S, Hamaya Y, Iizuka K, Igarashi Y, Minami M, Levi R, Hirafuji M. #147;Sphingosine 1-phosphate Inhibits Nitric Oxide Production induced by Interleukin-1{beta} in Rat Vascular Smooth Muscle Cells.#148; J Pharmacol Exp Ther. 2008 Apr;325(1):200-9.
• Kano S, Tyler E, Salazar-Rodriguez M, Estephan R, Mackins CJ, Veerappan A, Reid AC, Silver RB, Levi R. #147;Immediate Hypersensitivity Elicits Renin Release from Cardiac Mast Cells.#148; Int Arch Allergy Immunol. 2007 Dec 14;146(1):71-75.
• Heerdt PM, Lane P, Pan BY, Schaefer U, Crabtree M, Hong R, Singer AA, Levi R, Park BJ. #147;Nitrosative stress and myocardial sarcoplasmic endoreticular calcium adenosine triphosphatase subtype 2a activity after lung resection in swine.#148; Anesthesiology. 2007 Dec;107(6):954-62.
• Schaefer U, Machida T, Broekman MJ, Marcus AJ, Levi R. #147;Targeted deletion of ectonucleoside triphosphate diphosphohydrolase 1/CD39 leads to desensitization of pre- and postsynaptic purinergic P2 receptors.#148; J Pharmacol Exp Ther. 2007 Sep;322(3):1269-77.
• Reid AC, Silver RB, Levi R. #147;Renin: at the heart of the mast cell.#148; Immunol Rev. 2007 Jun;217:123-40.
• Levi R, Seyedi N, Schaefer U, Estephan R, Mackins CJ, Tyler E, Silver RB. #147;Histamine H3-receptor signaling in cardiac sympathetic nerves: Identification of a novel MAPK-PLA2-COX-PGE2-EP3R pathway.#148; Biochem Pharmacol. 2007 Apr 15;73(8):1146-56. Other Publications