Treatment of Chronic Depression
The current aims of Dr. Friedman's research are:
- To evaluate the efficacy of various antidepressant medications in the treatment of chronic depression.
- To study the effectiveness of long-term maintenance antidepressant treatment in chronic depression.
- To study the neurobiology of chronic depression.
- To study the social and occupational impairments of chronic depression.
Dr. Friedman is currently conducting the following clinical studies:
- A double blind comparison of sertraline versus imipramine for "double depression" (i.e., dysthymia with major depression) and chronic major depression for both short and long-term treatment.
- A double blind long-term study of desipramine versus placebo for dysthymia and other forms of chronic depression.
- A tryptophan depletion paradigm, which acutely lowers brain serotonin levels, to study the role of serotonin in chronic depression.