Dr. Golightly is currently involved in the development and validation of ligase detection reaction (LDR) techniques combined with PCR, capillary electrophoresis, and Universal Arrays to simultaneously differentiate multiple microbial pathogens in a single sample using microbial signature profiles. This work is being performed in collaboration with Drs. Francis Barany and Davise Larone of the Departments of Microbiology and Pathology, respectively. In parallel the group is developing techniques to detect food and waterborne pathogens in collaboration with investigators at the Noguchi Memorial institute for Medical Research in Accra, Ghana and the GHESKIO center in Port-au-Prince, Haiti. Dr. Golightly's laboratory is specifically involved in the development of techniques to detect Dengue, West Nile and other emerging pathogens in blood as well as viral and protozoan pathogens in fecal specimens. Dr. Golightly is also interested in the pathogenesis of cerebral malaria. With Dr. Shahin Rafii in the Department of Genetic Medicine and Dr. Ben Gyan and colleagues at the Noguchi Memorial institute for Medical Research in Accra, Ghana she is investigating the hypothesis that cerebral malaria occurs due an imbalance in microvascular homeostasis.