Publications
Original Research
Ruan, J., Xie, Q-w., Hutchinson, N., Cho, H., Wolfe, G. C., and Nathan, C. (1996) Inducible Nitric Oxide Synthase Requires Both the Canonical Calmodulin-binding Domain and Additional Sequences in Order to Bind Calmodulin and Produce Nitric Oxide in the Absence of Free Ca. J. Biol. Chem. 271:22679-86.
Shiloh, M. U., Ruan, J., and Nathan, C. (1997) Evaluation of Bacterial Survival and Phagocytes Function with a Fluorescence-Based Microplate Assay. Infect. Immun. 65:3193-98.
Ehrt, S., Shiloh, M. U., Ruan, J., Choi, M., Gunzburg, S., Nathan, C., Xie, Q.-w., and Riley, L. W. (1997) An Antioxidant Gene from Mycobacterium tuberculosis. J. Exp. Med. 186: 1885-96.
Ruan, J., St John, G., Ehrt, S., Riley, L., Nathan, C. (1999) noxR3, a Novel Gene from Mycobacterium tuberculosis, Protects Salmonella typhimurium from Nitrosative and Oxidative Stress. Infect. Immun. 67:3276-83.
St John, G., Brot, N., Ruan, J., Erdjument-Bromage, H., Tempst, P., Weissbach, H., Nathan, C. (2001) Peptide Methionine Sulfoxide Reductase from Escherichia coli and Mycobacterium tuberculosis Protects Bacteria against Oxidative Damage from Reactive Nitrogen Intermediates. Proc Natl Acad Sci U S A 98(17):9901-6.
Gotlib, J., Berubé, C., Growney, J. D., Chen, C.-C., George, T. I., Williams, C., Kajiguchi, T., Ruan, J., Lilleberg, S. L., Durocher, J. A., Lichy, J. H., Wang, Y., Cohen, P. S., Arber, D., Heinrich, M. C., Neckers, L., Galli, S. J., Gilliland, D. G., and Coutré, S. E. (2005) Activity of the Tyrosine Kinase Inhibitor PKC412 in a Patient with Mast Cell Leukemia with the D816V KIT Mutation. Blood. 106(8):2865-70.
Ruan, J., Hyjek, E., Kermani, P., Christos, P.J., Ikalowych, S., Coleman, M., Hempstead, B., Leonard, J.P., Chadburn, A. and Rafii, S. (2006) Magnitude of Stromal Hemangiogenesis Correlates with Histologic Subtype of Non-Hodgkins Lymphoma. Clin Cancer Res. 12(19):5622-31
Coleman, M., Martin, P., Ruan, J., et al. (2008) Low Dose Metronomic Multidrug Therapy with the PEPC (Prednisone, Etoposide, Procarbazine, and Cyclophosphamide) Oral Combination Chemotherapy Regimen for Mantle Cell Lymphoma. Leukemia & Lymphoma. 49(3):447-50.
Coleman, M., Martin, P., Ruan, J., et al (2008) The PEP-C (Prednisone, Etoposide, Procarbazine, and Cyclophosphamide) Oral Combination Chemotherapy Regimen for Relapsing Refractory Lymphoma: Low Dose Metronomic, Multidrug Therapy. Cancer. 112(10):2228-32.
Martin, P., Chadburn, A., Christos, P., Furman, R., Ruan, J., Joyce, M. A., Fusco, E., Glynn, P., Elstrom, R., Niesvizky, R., Feldman, E. J., Shore, T. B., Schuster, M. W., Ely, S., Knowles, D. M., Chen-Kiang, S., Coleman, M., Leonard, J. P. (2008) Intensive treatment strategies may not provide superior outcomes in mantle cell lymphoma: overall survival exceeding 7 years with standard therapies. Annals of Oncology. 19(7):1327-30.
Review Articles
Leonard, J. P., Furman, R. R., Ruan, J., Coleman, M. (2005) New Developments in Immunotherapy for Non-Hodgkins Lymphoma. Current Oncology Reports. 7(5):364-71.
Ruan, J. and Leonard, J. P. (2006) Mantle cell lymphoma: Current Concepts in Biology and Treatment. Cancer Treatment and Research. 131:141-59.
Leonard, J.P., Ruan, J., Martin, P., Coleman, M., Furman, R.R. (2007) New Agents in Development for Non-Hodgkins Lymphoma. Seminars in Hematology. 44:S18-21.
Martin, P., Furman, R. R., Ruan, J., Elstrom, R., Barrientos, J., Niesvizky, R., Coleman, M., Leonard, J. P. (2008) Novel and engineered anti-B-cell monoclonal antibodies for non-Hodgkin's lymphoma.
Seminars in Hematology. 45(2):126-32.
Leonard, J. P., Martin, P., Ruan, J., Elstrom, R., Barrientos, J., Coleman, M., Furman, R. R. (2008) New monoclonal antibodies for non-Hodgkin's lymphoma. Annals of Oncology. Suppl 4:iv60-2.
Ruan, J., Hajjar, K. A., Rafii, S., Leonard, J. P. (2008) Angiogenesis and Anti-angiogenic Therapy in Non-Hodgkins Lymphoma. Submitted.
Meeting Abstracts
Ruan, J., Q-w. Xie, N. Hutchinson, H. Cho, G. C. Wolfe, and C. Nathan. Calmodulin (CaM) binding region of mouse nitric oxide synthase-2 (residues 503-532) is necessary but not sufficient for CaM binding and nitric oxide production at trace calcium. American Society for Biochemistry and Molecular Biology Meeting, New Orleans, LA., June 2-6, 1996 (poster presentation).
Ruan, J., S. Ehrt, M. Shiloh, Q.-w. Xie, L. Riley, and C. Nathan. Anti-oxidant/anti-nitrosative gene from Mycobacterium tuberculosis: functional characterization in E. coli and S. typhimurium. The 5th International Meeting on Biology of Nitric Oxide. Kyoto, Japan, September 15-19, 1997 (podium presentation).
Gotlib, J., Berube, C., Ruan, J., Growney, J., Dugan, K., Falkow, R., Rosamilia, M., Resta, D., Cohen, P., Fabbro, D., Heinrich, M., Gilliland, D.G., Coutre, S. PKC412, inhibitor of the KIT tyrosine kinase, demonstrates efficacy in mast cell leukemia with the D816V KIT mutation. American Society of Hematology Annual Meeting, San Diego, CA, December 6-9, 2003 (poster presentation).
Ruan, J., Hyjek, E., Hooper, A.T., Vincent, L., Kermani, P., Christos, P.J., Ikalowych, S., Coleman, M., Hempstead, B., Leonard, J.P., Chadburn, A. and Rafii, S. Magnitude of Stromal Incorporation of VEGFR-1 , CD68 and -SMA Hemangiogenic Cells Distinguishes Histologic Subtypes of Non-Hodgkins Lymphoma. American Society of Hematology Annual Meeting, Atlanta, GA, December 10-13, 2005 (poster presentation).
Ruan, J., Coleman, M., Furman, R.R., Glynn, P., Joyce, M., Ketas, J., Cheung, K., Church, S., Shore, T., Feldman, E.J., Rutherford, S.C., Hyjek, E., Chadburn, A., Rafii, S., and Leonard, J.P. Targeting Angiogenesis in Mantle Cell Lymphoma: Clinical Efficacy and Correlative Studies of a Phase II Trial of RT-PEPC (Rituximab, Thalidomide and Metronomic Oral Chemotherapy with Prednisone, Etoposide, Procarbazine and Cyclophosphamide) in Relapsed/Refractory Disease. American Society of Hematology Annual Meeting, Orlando, FL, December 9-12, 2006 (poster presentation).
Hajjar, K.A., Ruan, J., Sui, G., Deora, A.B., Church, S., Cohen-Gould, L., Rafii, S., Lyden, D.C., Ling, Q. Annexin 2 Mediates Plasminogen-Related Recruitment of Neovascular Mural Cells in Lymphoma Angiogenesis. American Society of Hematology Annual Meeting, Atlanta, GA, December 8-11, 2007 (poster presentation)
Ruan, J., Coleman, M., Furman, R. R., Martin, P., Glynn, P., Joyce, M., Goodwin, J., Cheung, K., Feldman, E., Schuster, M., Shore, T., Leonard, J. P. Durable responses with the anti-angiogenic metronomic regimen RT-PEPC in recurrent mantle cell lymphoma (MCL). Lugano lymphoma meeting, Lugano, Switzerland, June 2008.
