Research Overview
Dr. Karwowski's primary research interests have focused on abdominal aortic aneurysm disease. He is also investigating endovascular simulation for better training of future vascular surgeons. Another area of research interest is new and advanced imaging techniques for peripheral vascular disease. Peer Reviewed Articles Karwowski JK, Markezich A, Whitson J, Abbruzzese TA, Zarins CK, Dalman RL. Dose-dependent limitation of arterial enlargement by the matrix metalloproteinase inhibitor RS-113,456.J Surg Res, 1999; 87:122-129. Mendoza AC, Karwowski JK, Zarins CK, Dalman RL. Increased flow limits enlargement of experimental aneurysms. ACS Surg Forum 1999; Vol L:425-428. Dalman RL, Abbruzzese TA, Yeung KK, Karwowski JK. Chronic spinal cord injury increases risk for abdominal aortic aneurysm disease. J Vasc Surg, 2000. Karwowski JK, Jeffrey RB, McDougall IR, Weigel RJ. Intraoperative ultrasonography improves identification of recurrent thyroid cancer. Surgery. 2002 Dec; 132(6):924-8; discussion 928-9. Nakahashi TK, Hoshina K, Tsao PS, Sho E, Sho M, Karwowski JK, Yeh C, Yang RB, Topper JN, Dalman RL. Flow loading induces macrophage antioxidative gene expression in experimental aneurysms. Arterioscler Thromb Vasc Biol. 2002 Dec 1;22(12):2017-22. Karwowski JK, Nowels KW, McDougall IR, Weigel RJ. Needle track seeding of papillary thyroid carcinoma from fine needle aspiration biopsy. A case report. Acta Cytol. 2002 May-Jun;46(3):591-5. Books, Book Chapters and Reviews Karwowski J, Dalman RL. Extra-anatomic bypass for aortoiliac occlusive disease. Ballard JL (Ed), Handbook of Aortic Surgery, Landes Bioscience, Georgetown, TX, 2000, pp 124-133. Karwowski J, Harris EJ. Conservative Treatment of Acute Subclavian Vein Thrombosis. Pearce WH, Matsamura JS, Yao JST (Ed), Trends in Vascular Surgery, Greenwood Academic, Evanston, IL, 2004, pp 355-363. Karwowski JK, Johnson B, Dalman RL. Upper extremity Ischemia: Diagnostic Techniques and Clinical Applications. Mansour MA, Labropoulos N, Vascular Diagnosis, Elsevier Saunders, Philadelphia, PA, 2005, pp 325-331. Karwowski J, Arko F. Surgical Management of Mesenteric Ischemia. Techniques in Vascular and Interventional Radiology. 2004 September; 7(3): 151-54 Presentations Karwowski JK, Abbruzzese TA, Martin RL, Zarins CK, Dalman RL. Dose-dependent limitation of chronic arterial enlargement by the matrix metalloproteinase inhibitor RS-113,456. American Heart Association 71st Scientific Sessions. Presented by John Karwowski, M.D. Dalman RL as PI and senior author. Dallas, TX, 11/8-11/98. Karwowski JK, Joshi S, Abbruzzese TA, Zarins CK, Dalman RL. Flow-dependent arterial enlargement requires matrix metalloproteinase (MMP) activity without increasing MMP-9 expression. Presented by John Karwowski, M.D., Dalman RL as PI and senior author. Seattle, WA, 11/19-22/98. The Sixth Annual Western Vascular Resident Forum, The Western Vascular Society Fourteenth Annual Meeting. Role of MMPs 2 and 9 in flow-mediated arterial enlargement. Presented by John Karwowski, M.D. Dalman RL as PI. Lake Tahoe, CA, 09/19/99. American College of Surgeons 85th Annual Clinical Congress, Surgical Forum. Increased flow limits enlargement of experimental aneurysms. Presented by John Karwowski, M.D., Dalman RL as PI. San Francisco, CA, 10/13/99. VA Research Seminar Series, Blood flow, inflammation, and arterial remodeling, presented by Dalman RL and Karwowski J. Auditorium, VA Palo Alto Health Care System, Palo Alto, CA, 03/09/2000. The Seventh Annual Western Vascular Resident Forum, The Western Vascular Society Fifteenth Annual Meeting. Increased flow limits enlargement of experimental aneurysms. Presented by John Karwowski, M.D.. Dalman RL as PI. Coeur DAlene, ID, 09/17/00. Association for Academic Surgery 34th Annual Meeting. Shear and strain mediate aortic enlargement following AVF creation. Presented by John Karwowski, M.D. Dalman RL as PI. Tampa, FL, 11/03/00. Society of University Surgeons 63rd Annual Meeting. High flow-mediated anti-oxidant gene expression inhibits experimental aneurysm enlargement: Role of heme oxygenase I. Nakahashi TK, Hoshina K, Yeh CCH, Karwowski JK, Dalman RL. Honolulu, HI, 02/14-16/02. 2002 AAVS/SVS Joint Annual Meeting, Wall shear stress modulates experimental aortic aneurysm enlargement. Hoshina K, Nakahashi TK, Karwowski JK, Mendoza AC, Dalman RL. Dalman RL as PI. Boston, MA, 06/09/02. Pacific Coast Surgical Association 76th Annual Meeting, Non-operative management of primary subclavian vein thrombosis. Karwowski JK, Harris EJ, Arko FA, Olcott IV C. Dana Point, CA, 2/20/05
