Research Overview
THE APPLICATION OF ULTRAFAST PAPANICOLAOU STAIN IN CYTOLOGY
I am interested in clinical reseach that directly effecting patient care. Back in 3/94, while as a junior faculty of this institution, I and a Cytopathology fellow shortened the Papanicolaou stain from 20 min. to 90 sec. as well as increasing the resolution of cellular details, thus named Ultrafast Papanicolaou stain (UFP). UFP allows cytopathologists to offer immediate diagnosis of FNA biopsies to the patients while they are waiting. Diagnostic clues enhanced by UFP include "grape-like" watery clear nuclei of follicular variant of papillary thyroid carcinoma; enhanced nuclear and cytoplasmic features to distinguish adenoid cystic carcinoma from look alike cylindromatous adenomas in salivary FNA; enhanced detection of Hodgkin cells in lymph node FNA; and the visualization of long microvilli of mesothelioma displayed within the retraction halos in pleural effusions. The data that I have collected in liver, pancreas, kidney, adrenal and retroperitoneum masses has been summarized in the recently published book.
