Research Grants:Current: NY Academy of Medicine/Valentine Research Award in Urology Role of p27 in Prostate Epithelial Cell Differentiation PI: Douglas S. Scherr, M.D. Total award: $50,000 Pfizer Corporation A Randomized, Placebo Controlled Phase II Study of Celecoxib in Patients with Recurrent Superficial Bladder Cancer PI: Douglas S. Scherr, M.D. Total Award: $25,000 Kidney Urology Foundation of AmericaCareer Development AwardThe Role of PIM-1 Oncogene in Prostate Carcinogenesis PI: Douglas S. Scherr, M.D. Total Award: $50,000 Edwin Beer Research Award Effective Tumor Immunotherapy in Superficial Bladder Cancer Total Award: $40,000/year for 2 yearsPending: NIH/NCI K23 Mentored Research Career Development Award Assignment Number: 1 K23 DK068111-01 BCG and Bladder Tumor Antigen Cross Presentation PI: Douglas S. Scherr, M.D. Total direct costs: $315,000 Priority Score: 180 3M PharmaceuticalsPhase I Trial of Imiquimod-like Coumpund in the Treatment of Superficial Bladder CancerPI: Douglas S. Scherr, M.D.Total Award: $345,000Active Protocols/Clinical Trials:Effective Tumor Immunotherapy in Bladder Cancer. Principal Investigator, Weill Medical College of Cornell University IRB # 0103-647, Approved 12/02, Renewed Approval 11/03. This protocol employs leukophoresis pre and post-BCG therapy in patients with superficial bladder cancer in an attempt to identify a specific CD-8 lymphocyte response to tumor antigen that is initiated by BCG. A total of 9 patients have enrolled and completed the trial. A Randomized, Placebo Controlled Phase II Study of Celecoxib in Patients with Recurrent Superficial Bladder Cancer, Co-PI at Cornell Site, Main PI: Dr. Guido Dalbagni, Memorial Sloan Kettering Cancer Center. Goal is to assess the role of Celecoxib in the prevention of superficial bladder cancer. Weill Medical College of Cornell University IRB # 0903-894.Role of Renal Biopsy in the Preoperative Determination of Histology in Patients with Renal Cell Carcinoma. Principal Investigator, Weill Medical College of Cornell University. Intraoperative renal biopsies performed prior to radical or partial nephrectomy with subsequent FISH analysis for pathological interpretation.