Publications
Xie Q, Cho H, Calaycay J, Mumford R, Swiderek K, Lee T, Ding A, Troso T, Nathan C. Cloning and characterization of inducible nitric oxide synthase from mouse macrophages. Science 256:225-228, 1992
MacMicking J, Nathan C, Hom G, Chartrain N, Trumbauer M, Stevens K, Xie Q, Sokol K, Fletcher D, Hutchinson N, Chen H, Mudgett J. Altered responses to bacterial infection and endotoxic shock in mice lacking inducible nitric oxide synthase. Cell 81:641-650, 1995
MacMicking J, North R, LaCourse R, Mudgett J, Shah S, Nathan C. Identification of NOS2 as a protective locus against tuberculosis. Proc Natl Acad Sci USA 94:5243-5248, 1997
Bryk R, Griffin P and Nathan C. Peroxynitrite reductase activity of bacterial peroxiredoxins. Nature 407, 211-215, 2000
Nathan, C. Inflammation: Points of control. Nature 420: 846-852, 2002.
Bryk, R, Lima C, Erdjument-Bromage H, Tempst P. Nathan C. Metabolic enzymes of mycobacteria linked to antioxidant defense by a thioredoxin-like protein. Science 295: 1073-1077, 2002
Darwin KH, Ehrt S, Gutierrez-Ramos JC, Weich N, Nathan C. The proteasome of Mycobacterium tuberculosis is required for resistance to nitric oxide. Science 302: 1963-1966, 2003
Nathan C. Antibiotics at the crossroads. Nature 431: 899-902, 2004
Nathan C. Neutrophils and immunity: Challenges and opportunities. Nature Reviews Immunol. 6: 173-182, 2006
Nathan C. Aligning pharmaceutical innovation with medical need. Nature Medicine 13: 304-308, 2007
Bryk R, Gold B, Venugopal A, Singh J, Samy R, Pupek K, Cao H, Popescu C, Gurney M, Hotha S, Cherian J, Rhee K, Ly L, Converse P, Ehrt S, Vandal O, Jiang X, Schneider J, Lin G, Nathan C. Selective killing of non-replicating mycobacteria. Cell Host and Microbe 3: 137-145, 2008
Gold, B., H. Deng, R. Bryk, D. Vargas, D. Eliezer, J. Roberts, X. Jiang, and C. Nathan. Identification of a copper-binding metallothionein in pathogenic mycobacteria. Nature Chemical Biology 4: 609-613, 2008
Vandal OH, Pierini LM, Schnappinger D, Nathan CF, Ehrt SE. A membrane protein preserves intrabacterial pH in intraphagosomal Mycobacterium tuberculosis. Nature Med. 14: 849-854, 2008
Nathan C. Taming tuberculosis: A challenge for science and society. Cell Host and Microbe 5: 220-4, 2009.
Nathan C and Ding A. Non-resolving inflammation. Cell 140: 871-882, 2010
de Carvalho LPS, Zhao H, Dickinson CE, Arango NM, Lima CD, Fischer SM, Ouerfelli O, Nathan C* and Rhee KY* (*co-corresponding authors). Activity-based metabolomic profiling of enzymatic function: Identification of Rv1248c as a mycobacterial 2-hydroxy-3-oxoadipate synthase. Chemistry and Biology 17: 323-332, 2010
Venugopal A, Bryk R, Shi S, Rhee K, Rath P, Schnappinger D, Ehrt S and Nathan C. Virulence of Mycobacterium tuberculosis depends on lipoamide dehydrogenase, a member of three multi-enzyme complexes. Cell Host and Microbe 9: 21-31, 2011.
Wu, K., Koo, J., Jiang, X., Chen, R., Cohen, S. N. and Nathan, C. Improved control of tuberculosis and activation of macrophages in mice lacking protein kinase R. PLoS ONE. 7: e30512, 2012.
Nathan C. Bacterial pathogenesis: Fresh approaches to anti-infective therapies. Science Translational Medicine 4: 1-13, 2012. A reprint can be obtained from:
