Publications
Kulczycki, A., Jr., Hempstead, B. L., Hoffman, S. L., Wood, E.W. and Parker, C.W. 1979. The Cell Surface Receptor for Immunoglobulin E. II. Properties of the Purified Receptor. J. Biol. Chem. 254: 3194-3200.
Hempstead, B. L., Parker, C. W. and Kulczycki, A. Jr. 1979. Characterization of the IgE Receptor Isolated from Human Basophils. J. Immunol. 123:2283-2291.
Hempstead, B.L., Parker, C.W. and Kulczycki, A., Jr. 1981. The Cell Surface Receptor for Immunoglobulin E. Effect of Tunicamycin on the Molecular Properties of the Receptor from Rat Basophilic Leukemia Cells. J. Biol. Chem. 256:10717-10723.
Hempstead, B.L., Kulczycki, A.,Jr. and Parker, C.W. 1981. Phosphorylation of the IgE Receptor from Ionophore A23187 Stimulated Rat Mast Cells. Bioch. Biophys. Res. Commun. 98:815-822.
Hempstead, B.L., Parker, C.W. and Kulczycki, A., Jr. 1983. Selective Phosphorylation of the IgE Receptor in Antigen-Stimulated Rat Mast Cells. Proc. Natl. Acad. Sci.USA 80:3050-3053.
Hempstead, B.L., Schleifer, L.S. and M.V. Chao. 1989. Expression of Functional Nerve Growth Factor Receptors After Gene Transfer. Science 243:373-375.
Hempstead, B.L., Patil, N., Thiel, B. and M. V. Chao. 1990. Deletion of Cytoplasmic Sequences of the NGF Receptor Leads to Loss of High Affinity Ligand Binding. J. Biol. Chem. 265:9595-9598.
Kaplan, D.R., Hempstead, B.L., Martin-Zanca, D., Chao, M.V. and Parada, L.F. 1991. The TRK Proto-Oncogene is a Receptor for Nerve Growth Factor. Science 252:554-558.
Hempstead, B.L., Martin-Zanca, D., Kaplan, D.R., Parada, L.F. and M.V. Chao. 1991. High Affinity NGF Binding Requires Co-expression of the TRK Proto-Oncogene and the Low Affinity NGF Receptor. Nature 350:678-683.
Pedraza, L. Frey, A. B., Hempstead, B.L., Colman, B.R., Salzer, J.L. 1991. Differential Expression of MAG Isoforms During Development. 1991. J. Neurosci Res. 29:141-148.
Berg, M.M., Sternberg, D., Hempstead, B.L., Chao, M.V. 1991. The Low Affinity NGF Receptor Mediates NGF-induced Tyrosine Phosphorylation. Proc. Natl. Acad. Sci. USA; 7106-7110.
Hempstead, B.L., Rabin, S.J., Kaplan, L., Reid, S., Parada, L.F. and D. R. Kaplan. 1991. Overexpression of the TRK tyrosine Kinase Rapidly Accelerates Nerve Growth Factor Induced Differentiation. Neuron 9, 1-20.
Hempstead, B.L., Birge, R. B., Fajardo, J.E., Mahadeo, D., Glassman, R., Kraemer, R. and Hanafusa, H. 1994.. Expression of the v-crk oncogene product in PC12 cells results in rapid differentiation by both NGF and EGF-dependent pathways. Mol. Cell Biol 14: 1964-1971.
Mahadeo, D., Kaplan, L. Chao, M.V. and Hempstead, B.L. 1994. High Affinity NGF Binding displays a faster rate of association than p140trk A binding: implications for multi-subunit polypeptide receptors. J. Biol. Chem., 269, 6884-6891.
Donovan, M.J., Hempstead, B.L., Horvath, C., Chao, M.V. and D. Schofield. 1994.. Immunohistochemical localization of trk receptor protein in pediatric small round blue cell tumors Am. J. Path. 143: 1560-1567.
Donovan, M.J., Huber, L.J., Hempstead, B.L., Tsoulfas, P., Kaplan, D.R., Parada, L.F., Chao, M.V. and Schofield, D. 1994. Expression of Neurotrophins and Neurotrophin Receptors in Wilm's Tumor. Am. J. Path. 145:792-801.
Donovan, M.J., Kraemer, R., McCafferty, T., Miranda, R., Tessorollo, L., Hajjar, D.P. and Hempstead, B.L. 1995. Neurotrophin and neurotrophin receptors in vascular smooth muscle cells: regulation of expression in response to injury, Am. J. Path. 147:309-324.
Chao, M.V. and Hempstead, B.L. 1995. p75 and trk: a two receptor system. Trends in Neuroscience 18: 321-326.
Muragaki, Y., Timothy, N., Leight, S., Hempstead, B.L., Chao, M.V., Trojanowski, J.Q. and V.M.-Y. Lee. 1995. Expression of trk receptors in the developing and adult human central and peripheral nervous system. J. Comp. Neurobiol. 356: 387-397.
Perez, P., Coll, P.M., Hempstead, B.L., Martin-Zanca, D., and M.V. Chao. 1995. NGF binding to the trk tyrosine kinase receptor requires the extracellular immunoglobulin-like domains. Mol. Cell. Neurosci. 6: 97-105.
Teng, K.K., Lander, H., Fajardo, J.E., Hanafusa, H., Hempstead, B.L. and R.B. Birge. 1995. v-crk modulation of growth factor induced PC12 cell differentiation involves the src homology 2 domain of v-crk and sustained activation of the ras/mitogen activated protein kinase pathway. J. Biol. Chem. 270: 20677-20685.
Lander, H.M., Milbank, A.J., Taurus, J., Hajjar, D., Hempstead, B., Schwartz, G, Kraemer, R., Mizra, U., Chait, B., Burk, S. and Quilliam,L. 1996. Redox regulation of cell signaling. Nature 381: 380-381.
Donovan, M.J., Hahn, R., Tessarollo, L. and Hempstead, B.L. 1996. Neurotrophin-3 is required for mammalian cardiac development:identification of an essential nonneuronal neurotrophin function. Nature Genetics 14: 210-213.
Glassman, R.G., Hempstead, B.L., Staino-Coico, L., Steiner, M., Hanafusa, H. and Birge, R.B. 1996. v-Crk, an effector for nerve growth factor signaling pathways, delays apoptotic cell death in neurotrophin-deprived PC12 cells. Cell Death and Differentiation 4: 82-93.
Huber, L.J., Hempstead, B.L. and Donovan, M.J. 1996. Neurotrophin and neurotrophin receptors in human fetal kidney. Dev. Biol. 179:369-381.
Teng, K.K., Courtney, J.C., van Bergen en Henegouwen, P., Birge, R.B. and Hempstead, B.L. 1996.Dissociation of NGF induced signal transduction from neurite elongation by expression of a mutant adaptor protein v-crk in PC12 cells. Mol. Cell. Neurosci. 8:157-170.
Melamed, I., Kelleher, C.A., Franklin, R.A., Brodie, C., Hempstead, B., Kaplan, D., Gelfand, E.W. 1996. Nerve growth factor signal transduction in human B lymphocytes is mediated by gp140trk. Eur. J. Immunol. 26:1985-92.
Lander, H.M., Hajjar, D.P., Hempstead, B.L., Mirza, U.A., Chait, B.T., Campbell, S., Quilliam, L.A. 1997. A molecular redox switch on p21(ras). Structural basis for the nitric oxide-p21 (ras) interaction. J. Biol. Chem. 272:4323-6.
Ryden, M., Hempstead, B. and Ibanez, C..F. 1997. Differential modulation of neuron survival during development by nerve growth factor binding to the p75 neurotropin receptor. J. Biol. Chem. 272:16322-16328.
Hempstead, B.L. and Chao, M.V. 1997. Entering the domain of neurotrophin binding. Nature Biotechnology, 15:623-624.
Das, I., Hempstead, B.L., MacLeish, P.R. and Sparrow, J.R. 1997. Immunohisto-chemical analysis of the neurotrophins BDNF, NT-3 and their receptors trkB, trkC, and p75 in the developing chick retina. Visual Neuroscience 14: 835-842.
Tessarollo, L., Tsoulfas, P., Donovan, M.J., Palko, M., Blair-Flynn, J., Hempstead, B.L. and Parada, L.F. 1997. Targeted deletion of all isoforms of the trk C gene suggests the use of alternative receptors by its ligand neurotrophin-3 in neural delvelopment and implicates trk C in normal cardiogenesis, Proc. Nat. Acad. Sci USA 94:14776-14781
Tessarollo, L. and Hempstead, B.L. 1998. Regulation of cardiac development by receptor tyrosine kinases, Trends in Cardiovascular Medicine 8:34-40.
Kraemer, R., March, K.L. and Hempstead, B.L. 1999 NGF activates similar intracellular signaling pathways in vascular smooth muscle cells as PDGF-BB but elicits different biological responses, Arteriosclerosis, Thrombosis and Vascular Biology 19: 1041-1050.
Das, I., Sparrow, J.R., Lin, M.L., Shih, E., Mikawa, T., Hempstead, B.L. 2000. Trk C signaling is required for retinal progenitor cell proliferation., J Neurosci 20:2887-95.
Teng, K.K., Esposito, D., Schwartz, G.M., Chao, M.V., Lander, H.M. and Hempstead, B.L. 1999. Activation of c-Ha-Ras by nitric oxide modulates survival responsiveness in neuronal PC12 cells, J. Biol Chem. 274:37315-20.
Escalante, M., Courtney, J., Chin, W.G., Teng, K.K., Kim, J.L., Fajardo, J.E., Mayer, B.J., Hempstead, B.L. and Birge, R.B. 2000. Phosphorylation of c-Crk II on the negative regulatory Tyr222 mediates nerve growth factor-induced cell spreading and morphogenesis, J. Biol. Chem. 275:24787-97.
Arevalo, J.C., Conde, B., Hempstead, B.L., Chao, M.V., Martin-Zanca, D., Perez, P. 2000. TrkA immunoglobulin-like ligand binding domains inhibit spontaneous activation of the receptor, Mol. Cell Biol. 20:5908-16.
Wang, S., Bray, P.J., McCaffrey, T.A., March, K., Hempstead, B.L., and Kraemer, R. 2000. Ligand induced activation of p75NTR by neurotrophins induced apoptosis vascular smooth muscle cells, Amer. J. Path., 157:1247-1258.
Donovan, M.J., Lin, M.I., Wiegn, P., Ringsted, R., Kraemer, R., Hahn, R., Wang, S., Ibanez, C., Rafii, S., Hempstead, B.L. 2000. Brain derived neurotrophic factor is an endothelial cell survival factor required for intramyocardial vessel stabilization, Development, 127:4531-4540.
Lin, M.I., Das, I., Schwartz, G.M., Tsoulfas, P., Mikawa, T., and Hempstead, B.L. 2000. Trk C receptor signaling regulates cardiac myocyte proliferation during early heart development in vivo, Developmental Biology, 226:180-191.
Arevalo, J.C., Conde, B., Hempstead, B.L., Chao, M.V., Martin-Zanca, D., and Perez, P. 2001. A novel mutation within the extracellular domain of trk A causes constituitive receptor activation. Oncogene, 20:1229-34.
Esposito, D., Patel, P., Stephens, R.M., Perez, P., Chao, M.V., Kaplan, D.R., Hempstead, B.L. 2001. The cytoplasmic and transmembrane domains of the p75 and Trk A receptors regulate high affinity binding to NGF. J Biol Chem 276:32687-32695.
Lee, R., Kermani, P., Teng, K., Hempstead, B.L. 2001. The pro-NGF precursor dictates pro-apoptotic or pro-survival outcomes through differential receptor binding. Science 294: 1945-1948
Hempstead, B.L. 2002. The many faces of p75. Current Opin in Neurobiology, 12:260-260-267..
Yu, X., Shacka, J.J., Fells, J.B., Suarez-Quian, C., Przygodzki, R.M., Beleslin-Cokic, B., Lin, C.S., Nikodem, V.M., Hempstead,B., Flanders, K.C., Costantini, F., Noguchi, C.T. 2002. Erythropoietin receptor signaling is required for normal brain development. Development, 129:505-16.
Beattie, M.S., Harrington, A.W., Lee, R., Kim, J.Y., Boyce, S.L., Longo, F.M., Breshnahan, J.C., Hempstead, B.L. and Yoon, S.O 2002 Pro-NGF induces p75-mediated death of oligodendrocytes following spinal cord injury. Neuron. 36, 375-86.
Hempstead, B.L. and J.L. Salzer. 2002 A glial spin on neurotrophins, Science, 298, 1184-6.
Shonukan, O, Bagayogo I, McCrea, P, Chao, M , Hempstead, B. 2003. Neurotrophin-induced melanoma migration is mediated through the actin-bindling protein fascin. Oncogene 22, 3616-3623.
Kraemer, R, and Hempstead, BL. 2003. Neurotrophins: novel mediators of angiogenesis. Frontiers in Bioscience, 8: 1184-86.
Zhou, H, Weskamp, G, Sahin, U, Chesneau V, Chiusaroli R, Hahn R, Wilkes D, Fisher P, Baron R Manova K,Basson C, Hempstead BL and Blobel C. 2004 Essential role for ADAM19 in cardiovascular morphogenesis. Mol Cell Biol 24: 96-104.
Ling, Q, Jacovina, AT, Deora, AB, Febbraio M, Simantov R, Silverstein R, Hempstead, B, Mark, WH, Hajjar, KA. 2004. Annexin II regulates cell surface plasmin generation in vivo:fibrin homeostasis and neuoangiogenesis. J Clin Invest,113: 38-48.
Teng, KK and Hempstead, BL.2004. Neurotrophins and their receptors:signaling trios in complex biological systems. Cell Mol. Life Sciences 61: 35-48.
Murray, SS, Perez, P., Lee, R, Hempstead, BL, Chao, MV. A novel neurotrophin receptor-related preotein, NRH2, regulates NGF binding to the TRk A receptor. J. Neurosci 24, 2742-2749.
Harrington, AW, Leiner B, Blechschmitt C, Arevalo, JC, Lee R, MorlK, Meyer M, Hempstead BL. Yoon SO, Giehl KM. 2004. Secreted proNGF is a pathophysiological death-inducing ligand after adult CNS injury. Proc Natl Acad Sci 101:2742- 2749.
Kermani, P, Rafii, D, Jin DK, Whitlock P, Schwarz W, Chiang, Vincent L, Friedrich M, Shido K, Hackett NR, Crystal RG, Rafii, S, Hempstead BL. 2005 Neurotrophins promote revascularization by local recruitment of TrkB endothelial cells and systemic mobilization of hematopoietic progenitors. J Clin Invest 115: 653-663.
Nykjaer A, Lee R, Teng KK, Jansen P, Madsen P, Nielsen MS, Jacobsen C., Kliemannel M, Schwarz E, Willnow TE, Hempstead BL, Petersen CM. 2004. A novel neurotrophin receptor essential for proNGF induced neuronal cell death. Nature, 427: 843-848.
Chen ZH, Patel PD, Sant G, Meng CX, Teng KK, Hempstead BL. Lee FS. 2004. Variant brain-derived neurotrophic factor (BDNF) (Met66) alters the intracellular trafficking and activity dependent secretion of wild-type BDNF in neurosecretory cells and cortical neurons. J Neurosci, 24:4401-4411.
Hempstead BL 2004. Sculpting organ innervation. J. Clin Invest.113: 811-3.
Srinivasan B, Roque CH, Hempstead BL, Al-Ubaidi MR, Roque RS. 2004. Microglia-derived pronerve growth factor promotes photoreceptor cell death via p75 neurotrophin receptor. J Biol Chem. 279(40):41839-45.
Kim, H, Li Q, Hempstead BL, Madri JA. 2004 Paracrine and autocrine functions of brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF) ub brain-derived endothelial cells. J. Biol Chem. 279: 33538-46.
Pang, PMW, Teng H, Teng, KK, Cheng, S. Zaitsev E, Sakata K, Yung WH, Hempstead BL, Lu B. 2005. Proteolytic conversion from pro-to-mature BDNF by tPA/plasmin is essential for long-term hippocampal plasticity. Science, 306:487-91.
Pearse RN, Swendeman SL, Li Y, Rafii D, Hempstead BL. 2005. A neurotrophin axis in myeloma: TrkB and BDNF promote tumor cell surival. Blood. 105:4429-36.
Linggi MS, Burke TL, Williams BB, Harrington A, Kraemer R, Hempstead BL, Yoon SO, Carter BD. 2005. NRIF is an essential mediator of apoptotic signaling by the p75 neurotrophin receptor. J Biol Chem. 280:13801-8.
Pedraza CE, Podlesniy P, Vidal N, Arevalo JC, Lee R, Hempstead B, Ferrer I, Iglesias M, Espinet C. 2005. Pro-NGF isolated from the human brain affected by Alzheimer's disease induces neuronal apoptosis mediated by p75NTR. Am J Pathol. 166:533-43.
Klein M, Hempstead BL, Teng KK. 2005. Activation of STAT5-dependent transcription by the neurotrophin receptor Trk. J Neurobiol. 63:159-71
Shmelkov SV, Meeus S, Moussazadeh N, Kermani P, Rashbaum WK, Rabbany SY, Hanson MA, Lane WJ, St Clair R, Walsh KA, Dias S, Jacobson JT, Hempstead BL, Edelberg JM, Rafii S. 2005 Cytokine preconditioning promotes codifferentiation of human fetal liver CD133 stem cells into angiomyogenic tissue. Circulation 111(9):1175-83.
Hempstead BL, 2005. Coupling neurorophins to cell migration through selective guanine nucleotide exchange factor activation. Proc National Acad Sci USA 102:5645-6.
Teng HK, Teng KK, Lee R, Wright S, Tevar S, Almeida RD, Kermani P, Torkin R, Chen ZY, Lee FS, Kraemer RT, Nykjaer A, Hempstead BL. 2005 ProBDNF induces neuronal apoptosis via activation of a receptor complex of p75NTR and sortilin. J Neurosci 25:5455-63.
Chen ZY, Ieraci A, Teng H, Dall H, Meng CX, Herrera DG, Nykjaer A, Hempstead BL, Lee FS. 2005. Sortilin controls intracellular sorting of brain-derived neurotrophic factor to the regulated secretory pathway. J Neurosci. 25:6156-66.
Zhang F, Cheng, J Lam G, Jin DK, Vincent L, Hackett NR, Wang S, Young LM Hempstead BL, Crystal RG, Rafii, S. 2005. Adenovirus vector E4 gene regulates connexin 40 and 43 expression in endothelial cells via PKA and PI3K signal pathways. Circ Res. 96: 950-7.
Woo NH, Teng HK, Siao CJ, Chiaruttini C, Pang PT, Milner TA, Hempstead BL, Lu B. 2005. Activation of p75(NTR) by proBDNF facilitates hippocampal long-term depression. Nature Neuroscience. 8:1069-77.
Kermani, P, Rafii D, Jin DK, Whitlock P, Schaffer W, Chiang A, Vincent L, Friedrich M, Shido K, Hackett NR, Crystal RG, Raffi S, Hempstead BL 2005. Neurotrophins promote revascularization by local recruitment of TrkB endothelial cells and systemic mobilization of hematopoietic progenitors. J.Clin Invest 115:653-63. With Commentary. J. Clin Invest 115:596-598.
Kraemer R, Baker PJ, Kent KCm Ye Y, Han JJ, Tejada R, Silane M, Upmacis R, Deeb R, Chen Y, Levine DM, Hempstead B. 2005 Decreased neurotrophin TrkB receptor expression reduces lesion size in the apolipoproteinE-null mutant mouse. Circulation 112-3644-53.
Hempstead BL. 2006 Dissecting the diverse actions of pro- and mature neurotrophins. Current Alzheimer’s Research, 3: 19-24.
Massa, SM, Xie Y, Yang T, Harrington AW, Kim ML, Yoon SO, Kraemer R, Moore LA, Hempstead BL, Longo, FM. 2006 Small, nonpeptide p75NTR ligands induce survival signaling and inhibit proNGF-induced death. J. Neurosci, 26: 5288-5300.
Kenchappa RS, Zampieri N, Chao MV, Barker PA, Teng HK, Hempstead BL, Carter BD. 2006 Ligand-dependent cleavage of the P75 neurotrophin receptor is necessary for NRIF nuclear translocation and apoptosis in sympathetic neurons. Neuron. 50:219-32.
Hempstead BL. 2006. Dissecting the diverse actions of pro- and mature neurotrophins. Curr Alzheimer Res 3(1):19-24.
Volosin M, Song W, Almeida RD, Kaplan DR, Hempstead BL, Friedman WJ. 2006 Interaction of survival and death signaling in basal forebrain neurons: roles of neurotrophins and proneurotrophins.J Neurosci. 26:7756-66.
Turner BA, Sparrow J, Cai B, Monroe J, Mikawa T, Hempstead BL. 2006 TrkB/BDNF signaling regulates photoreceptor progenitor cell fate decisions. Dev Biol. 299:455-65
Ruan J, Hyjek E, Kermani P, Christos PJ, Hooper AT, Coleman M, Hempstead B, Leonard JP, Chadburn A, Rafii S. 2006 Magnitude of stromal hemangiogenesis correlates with histologic subtype of non-Hodgkin's lymphoma. Clin Cancer Res. 12:5622-31
Chen ZY, Jing D, Bath KG, Ieraci A, Khan T, Siao CJ, Herrera DG, Toth M, Yang C, McEwen BS, Hempstead BL, Lee FS. 2006 Genetic variant BDNF (Val66Met) polymorphism alters anxiety-related behavior.
Science. 314:140-3.
Domeniconi M, Hempstead BL, Chao MV 2006 Pro-NGF secreted by astrocytes promotes motor neuron cell death. Mol Cell Neurosci. 34:271-9.
Kermani, P, Hempstead B. 2007 Brain-derived neurotrophic factor: a newly described mediator of angiogenesis. Trends in Cardiovasc Med. 17:140-3.
Johnston AL, Lun X, Rahn JJ, Liacini A, Wang L, Hamilton MG, Parney IF, Hempstead BL, Robbins SM, Forsyth PA, Senger DL. 2007. The p75 neurotrophin receptor is a central regulator of glioma invasion. PloS. Biol. 5(8):e212.
Jansen P, Giehl K, Nyengaard JR, Teng K, Lioubinski O, Sjoegaard SS, Breiderhoff T, Gotthardt M, Lin F, Eilers A, Petersen CM, Lewin GR, Hempstead BL, Willnow TE, Nykjaer A. 2007. Roles for the pro-neurotrophin receptor sortilin in neuronal development, aging and brain injury. Nat Neurosci.
Truzzi F, Marconi A, Lotti R, Dallaglio K, French LE, Hempstead BL, Pincelli C. 2008. Neurotrophins and their receptors stimulate melanoma cell proliferation and migration.J Invest Dermatol.
Bath KG, Mandairon N, Jing D, Rajagopal R, Kapoor R, Chen ZY, Khan T, Proenca CC, Kraemer R, Cleland TA, Hempstead BL, Chao MV, Lee FS. 2008 Variant brain-derived neurotrophic factor (Val66Met) alters adult olfactory bulb neurogenesis and spontaneous olfactory discrimination.J Neurosci.
Chen ZY, Bath K, McEwen B, Hempstead B, Lee F. 2008. Impact of genetic variant BDNF (Val66Met) on brain structure and function.Novartis Found Symp
Volosin M, Trotter C, Cragnolini A, Kenchappa RS, Light M, Hempstead BL, Carter BD, Friedman WJ. 2008 Induction of proneurotrophins and activation of p75NTR-mediated apoptosis via neurotrophin receptor-interacting factor in hippocampal neurons after seizures.J Neurosci.
Yang J, Siao CJ, Nagappan G, Marinic T, Jing D, McGrath K, Chen ZY, Mark W, Tessarollo L, Lee FS, Lu B, Hempstead BL. 2009. Nat Neurosci.
Nagappan G, Zaitsev E, Senatorov VV Jr, Yang J, Hempstead BL, Lu B. 2009. Control of extracellular cleavage of ProBDNF by high frequency neuronal activity.Proc Natl Acad Sci
Bath KG, Voss HU, Jing D, Anderson S, Hempstead B, Lee FS, Dyke JP, Ballon DJ. 2009. Quantitative intact specimen magnetic resonance microscopy at 3.0 T.Magn Reson Imaging
