Publications
Burroughs M, Moscona A. Immunization of pediatric solid organ transplant candidates and recipients . Clinical Infectious Diseases. 30 (6): 857-869, 2000.
Moscona A. Management of respiratory syncytial virus infections in the immunocom-promised child. Pediatric Infectious Disease Journal 19 (3): 253, 2000.
Greengard O, Poltoratskaia N, Leikina E, Zimmerberg J, Moscona A. The anti-influenza virus agent 4-GU-DANA (Zanamivir) inhibits cell fusion mediated by human parainfluenza virus and influenza virus HA. Journal of Virology 74: 11108-11114, 2000.
Horga M-A, Gusella G-L, Poltoratskaia N, Greengard O, Porotto M, Moscona A. Mechanism of viral interference mediated by human parainfluenza virus type 3. Journal of Virology 74: 11792-11799, 2000.
Parisien J-P, Lau JF, Sullivan BM, Rodriguez JJ, Moscona A, Parks GD, Lamb RA, Horvath CM. The V protein of human parainfluenza virus 2 antagonizes type I interferon responses by destabilizing signal transducer and activator of transcription 2. Virology 283, 230-239, 2001.
Murrell M, Greengard O, Porotto M, Poltoratskaia N, Moscona A. A single amino acid alteration in the human parainfluenza virus type 3 hemagglutinin-neuraminidase glycoprotein confers resistance to the inhibitory effects of Zanamivir on receptor binding and neuraminidase activity. Journal of Virology 75: 6310-6320, 2001.
Porotto M, Greengard O, Poltoratskaia N, Horga M-A, Moscona A. Human parainfluenza virus type 3 HN-receptor interaction: effect of 4-guanidino-Neu5Ac2en on a neuraminidase-deficient variant. Journal of Virology 75: 7481-7488, August 2001.
Prince GA, Ottolini MG, Moscona A. Contribution of the human parainfluenza virus type 3 HN-receptor interaction to pathogenesis in vivo. Journal of Virology 75: 12446-51, 2001.
Murrell M, Porotto M, Weber T, Greengard O, Moscona A. Mutations in human parainfluenza virus type 3 hemagglutinin-neuraminidase causing increased receptor binding activity and resistance to the transition state sialic acid analog 4-GU-DANA (Zanamivir). Journal of Virology 77 (1): 309-317, 2003.
Porotto M, Greengard O, Murrell M, Moscona A. Triggering of human parainfluenza virus 3 fusion protein (F) by the hemagglutinin-neuraminidase (HN) protein: an HN mutation diminishes the rate of F activation and fusion. Journal of Virology 77(6): 3647-3654, 2003.
Porotto M, Murrell M, Greengard O, Lawrence M, McKimm-Breschkin JL, Moscona A. Inhibition of parainfluenza virus type 3 and Newcastle disease virus hemagglutinin-neuraminidase receptor binding: Effect of receptor avidity and steric hindrance at the inhibitor binding sites. Journal of Virology 78 (24): 13911-13919, 2004.
Moscona A. Oseltamivir-resistant influenza? Lancet 364: 9436, 733-4, 2004.
Porotto M, Murrell M, Doctor L, Greengard O, Moscona A. Influence of the human parainfluenza virus 3 attachment protein’s neuraminidase activity on its capacity to activate the fusion protein. Journal of Virology 79 (4): 2383-2392, 2005.
Moscona A. Entry of parainfluenza virus into cells as a target for interrupting childhood respiratory disease. The Journal of Clinical Investigation 115: 1688-1698.
Moscona A. Neuraminidase inhibitors for influenza. New England Journal of Medicine 353:1363-1371, 2005.
Moscona A. Oseltamivir resistance – Disabling our influenza defenses. New England Journal of Medicine 353: 2634-2636, Dec 22, 2005.
Porotto M, Fornabaio M, Greengard O, Murrell MT, Kellogg GE, Moscona A. Paramyxovirus receptor-binding molecules: Engagement of one site on the hemagglutinin-neuraminidase protein modulates activity at the second site. Journal of Virology 80 (3): 1204-1213, 2006.
Porotto M, Doctor L, Carta P, Fornabaio M, Greengard O, Kellogg GE, Moscona A. Inhibition of Hendra virus fusion. Journal of Virology 80 (19): 9837-9849, 2006.
DeLaMora P, Moscona A. A daring treatment and a successful outcome: The need for targeted therapies for pediatric respiratory viruses. Pediatric Transplantation 11(2): 121-123, 2007.
Porotto M, Fornabaio M, Kellogg GE, Moscona A. A second receptor binding site on human parainfluenza virus type 3 hemagglutinin-neuraminidase contributes to activation of the fusion mechanism. Journal of Virology 81(7): 3216-28, 2007.
Palermo LM, Porotto M, Greengard O, and Moscona, A. Fusion promotion by a paramyxovirus hemagglutinin-neuraminidase protein: pH modulation of receptor avidity of binding sites I and II by pH. Journal of Virology 81 (17), 9152-9161, 2007 (Palermo and Porotto are co-first authors.)
Porotto M, Carta P, Deng Y, Kellogg GE, Whitt M, Lu M, Mungall BA, Moscona, A. Molecular determinants of antiviral potency of paramyxovirus entry inhibitors. Journal of Virology 81 (19): 10567-74, 2007.
Moscona A. CSI Microbiology: Emerging pathogens and a staged strategy for detection and discovery. Journal of Infectious Diseases 196: 1727-8, 2007.
Aljofan M, Porotto M, Moscona A, Mungall BA. Development and validation of a chemiluminescent immunodetection assay amenable to high throughput screening of antiviral drugs for Nipah and Hendra virus. Journal of Virological Methods 149(1):12-9, 2008.
Matteo Porotto, Gianmarco Orefice, Christine Yokoyama, Bruce Mungall, Ronald Realubit, Mike Sganga, Mohamad Aljofan, Michael Whitt, Fraser Glickman and Anne Moscona. Simulating henipavirus multicycle replication in a screening assay leads to identification of a promising candidate for therapy. J Virol. Mar 4, 2009 [Epub ahead of print]. (Editor’s Spotlight)
Anne Moscona. Global Transmission of Oseltamivir-Resistant Influenza. N Engl J Med. Mar 5;360(10):953-6, 2009.
Matteo Porotto, Christine Yokoyama, Gianmarco Orefice, Han-Sung Kim, and Anne Moscona. Kinetic dependence of paramyxovirus entry inhibition. In press, J. Virol., 2009
Laura Palermo, Matteo Porotto, Christine Yokoyama, Samantha Palmer, Olga Greengard, Stefan Niewiesk, and Anne Moscona. Human parainfluenza virus infection of the airway epithelium: the viral hemagglutinin-neuraminidase regulates F-triggering and modulates infectivity. In press, J. Virol. 2009
