Publications
Xia, J., Peng, Y., Mian, I.S., & Lue, N.F. Identification of functionally important domains in the N-terminal region of telomerase reverse transcriptase. Mol. Cell. Biol. 20: 5196-5207 (2000).
Peng, Y., Mian, I.S., and Lue, N.F. Telomerase processivity as a determinant of telomere length. Molecular Cell 7:1201-1211 (2001).
Singh, S., Steinberg-Neifach, O., Mian, I.S., and Lue, N.F. Analysis of Candida telomerase: a potential role in telomere end protection. Eukaryotic Cell 1: 967-977 (2002).
Singh, S., and Lue, N.F. Ever Shorter Telomere 1 (EST1)-dependent reverse transcription by Candida telomerase in vitro: evidence in favor of an activating function. Proc. Natl. Acad. Sci. USA 100: 5718-5723 (2003).
Bosoy, D., Peng, Y., Mian, I. S., and Lue, N.F. Conserved N-terminal motifs of telomerase reverse transcriptase required for ribonucleoprotein assembly in vivo. J. Biol. Chem. 278: 3882-3890 (2003).
Lue, N.F., Lin, Y.-C., and Mian, I.S. A conserved telomerase motif in the catalytic domain of telomerase reverse transcriptase is specifically required for repeat addition processivity. Mol. Cell. Biol. 23: 8440-8449 (2003).
Lue, N.F. Adding to the ends:what makes telomerase processive and how important is it? Bioessay 26: 955-962 (2004).
Lue, N.F. A physical and functional constituent of telomerase anchor site. J. Biol. Chem. 280: 26586-6591 (2005).
Lue, N.F., Bosoy, D., Moriarty, T., Autexier, C., Altman, B., and Leng, S. Telomerase can act as a template- and RNA-independent terminal transferase. Proc. Natl. Acad. Sci. USA 102: 9778-978, (2005).
Autexier, C. and Lue, N.F. The structure and function of telomerase reverse transcriptase. Ann. Rev. Biochem. 75: 493-517 (2006).
Yu, E.Y., Steinberg-Neifach, O., Dandjinou, T.A., Kang, F., Morrison, A., Shen, X., and Lue, N.F. Regulation of telomere structure and function by subunits of the INO80 chromatin remodeling complex. Mol. Cell. Biol. 27: 5639-5649 (2007).
Hsu, M., Yu, E.Y., Singh, S.M., and Lue, N.F. The mutual dependence of Candida Est1p and Est3p in telomerase assembly and activation. Euk. Cell 6: 1330-1338 (2007).
Hsu, M., McEachern, M.J., Dandjinou, T.A., Tzfati, Y., Orr, E., Blackburn, E.H., and Lue, N.F. The Candida albicans telomerase core components protect telomeres from aberrant degradation. Proc. Natl. Acad. Sci. USA 104: 11682-11687 (2007).
Lue, N., and Li, Z. Modeling and structure function analysis of the putative anchor site of yeast telomerase. Nucl. Acids Res. 35: 5213-5222 (2007).
Yu, E., Wang, F., Lei, M., and Lue, N.F. A proposed OB-fold structure with a protein-interaction surface in the Candida albicans telomerase protein Est3. Nat. Struc. Mol. Biol. 15: 985-989 (2008).
Lue, N.F. Closing the feedback loop: how cells count telomere bound proteins. Mol. Cell 33: 413-414 (2009).
Sun, J., Yu, E.Y., Yang, Y., Confer, L.A., Sun, S., Wan, K., Lue, N.F., and Lei, M. Stn1-Ten1 is an Rpa2-Rpa3-like complex at telomeres. Genes & Dev. 23: 2900-2914 (2009).
Lue, N.F. The plasticity of telomere maintenance mechanisms in yeast. Trends Biochem. Sci. 35: 8-17 (2010).
Yu, E.Y., Yen, W.-F., Steinberg-Neifach, O., and Lue, N.F. Candida albicans Rap1: an unusual structural organization and a critical function in suppressing telomere recombination. Mol. Cell. Biol. 30: 1254-1268 (2010).
Sun, J., Yang, Y., Wan, K., Mao, N., Yu, T.-Y., Lin, Y.-C., DeZwaan, D.C., Freeman, B.C., Lin, J.-J., Lue, N., Lei, M. Structural bases of dimerization of yeast telomere protein Cdc13 and its interaction with the catalytic subunit of DNA polymerase a. Cell Research 21: 258-274 (2011).
Yen, W.-F., Chico, L., Lei, M., and Lue, N.F. The telomerase regulatory protein Est3 in two Candida species physically interacts with both the TEN domain of TERT and telomeric DNA. Proc. Natl. Acad. Sci USA 108:20370-20375 (2011) .
Chico, L., Ciudad, T., Hsu, M., Lue, N.F., and Larriba, G. The Candida albicans Ku70 modulates telomere length and structure by regulating both telomerase and recombination. PLoS One 6: e23732 (2011).
Belfort, M., Curcio, M.J., and Lue, N.F. Reverse transcriptase that shaped genomes: retrotransposons and telomerases. Proc. Natl. Acad. Sci. USA 108: 20304-20310 (2011).
Yu, E.Y., Sun, J., Lei, M., and Lue, N.F. Analyses of Candida Cdc13 orthologues revealed a novel OB fold dimer arrangement, dimerization-assisted DNA-binding, and substantial structural differences between Cdc13 and RPA70. Mol. Cell. Biol. 32: 186-198 (2012).
Hsu, M., Yu, E. Y., Sprušanský, O., McEachern, M.J., and Lue, N.F. Functional analysis of the single Est1/Ebs1 homologue in K. lactis reveals roles in both telomere maintenance and rapamycin resistance. Eukaryotic Cell, in press (2012).
