Publications

Selected Publications:

  • Choi, J.B., Gordon, G.R.J., Zhou, N., Tai, C., Rungta, R.L., Martinez, J., Milner, T.A., Ryu, J.K., McLarnon, J.G., Tresguerres, M., Levin, L.R., Buck, J., and MacVicar, B.A. (2012). Metabolic communication between Astrocytes and Neurons via Bicarbonate-responsive soluble Adenylyl Cyclase. Neuron 75: 1094-1104.
  • Salazar E, Bank EM, Ramsey N, Hess KC, Deitsch KW, Levin LR, Buck J. (2012). Characterization of Plasmodium falciparum Adenylyl Cyclase-β and Its Role in Erythrocytic Stage Parasites. PLoS One 2012;7(6): e39769.
  • Lee, Y-S., Tresguerres, M., Hess, K., Marmorstein, L.Y., Levin, L.R., Buck, J., and Marmorstein, A.D. (2011). Regulation of anterior chamber drainage by bicarbonate sensitive adenylyl cyclase in the ciliary body. J. Biol. Chem.286: 41353-8..
  • Acin-Perez, R., Russwurm, M., Gunnewg, K., Gertz, M., Zoidl,G., Ramos, L., Buck, J., Levin, L.R., Rassow, J., Manfredi, G., and Steegborn, C. (2011). A phosphodiesterase 2A isoform localized to mitochondria regulates respiration. JBC 286: 30423-30432.
  • Tresguerres, M, Levin, L.R., and Buck, J. (2011). Signaling by Soluble Adenylyl Cyclase. Kidney International 79:1277-1288.
  • Tresguerres, M, Buck, J.,and Levin, L.R. (2010). Physiological carbon dioxide, bicarbonate and pH sensing. Pflugers Archiv - European Journal of Physiology 460:953-964.
  • Tresguerres, M, Levin, L.R., Buck, J., and Grosell, M. (2010). Modulation of NaCl absorption by [HCO3-] in the marine teleost intestine is mediated by soluble adenylyl cyclase. AJP-Regulatory, Integrative and Comparative Physiology 299:R62-R71.
  • Tresguerres, M., Parks, S.K., Salazar, E., Levin, L.R., Goss, G.G, and Buck, J. (2010). Bicarbonate-sensing soluble Adenylyl Cyclase is an essential sensor for acid-base homeostasis. Proc. Natl. Acad. Sci. 107: 442-447.
  • Acin-Perez, R., Salazar, E., Kamenetsky, M., Buck, J., Levin, L.R., and Manfredi, G. (2009). Cyclic AMP produced inside mitochondria regulates oxidative phosphorylation. Cell Metabolism 9: 265-276.
  • Ramos, L.*, Zippin, J.H.*, Kamenetsky, M., Buck, J., and Levin, L.R. (2008). Glucose and GLP-1 stimulate cAMP production via distinct adenylyl cyclases in INS-1E insulinoma cells. J. Gen. Physiology 132: 329-338.
  • Schmid, A., Sutto, Z., Nlend, M., Horvath, G., Schmid, N., Buck, J., Levin, L.R., Conner, G., Fregien, N., and Salathe, M. (2007). Soluble adenylyl cyclase is localized to cilia and contributes to ciliary beat frequency regulation via production of cAMP. J. Gen. Physiology. 130: 99-109.
  • Wu, K.Y., Zippin, J.H., Huron, D.R., Kamenetsky, M., Hengst, U., Buck, J., Levin, L.R., and Jaffrey, S.R. (2006). Soluble adenylyl cyclase is required for netrin-1 signaling in nerve growth cones. Nature Neurosci. 9: 1257-1264.
  • Stessin, A.M., Zippin, J.H., Kamenetsky, M., Hess, K.C., Buck, J., and Levin, L.R. (2006). Soluble adenylyl cyclase mediates NGF-induced activation of RAP1. J. Biol. Chem. 281: 17253-17258.
  • Klengel T, Liang WJ, Chaloupka J, Ruoff C, Schroppel K, Naglik JR, Eckert SE, Mogensen EG, Haynes K, Tuite MF, Levin LR, Buck J, Muhlschlegel FA. (2005) Fungal adenylyl cyclase integrates CO2 sensing with cAMP signaling and virulence. Current Biology 15(22):2021-6.
  • Han, H., Stessin, A.M., Roberts, J., Hess, K.C., Gautam, N., Kamenetsky, M., Lou, O., Hyde, E., Nathan, N., Muller, W.A., Buck, J., Levin, L.R., and Nathan, C. (2005). Role of Calcium-Sensing Soluble Adenylyl Cyclase in TNF Signal Transduction in Human Neutrophils. J. Exp. Med. 202: 353-361.
  • Hess, K.C.*, Jones, B.H.*, Marquez, B., Chen, Y., Ord, T.S., Kamenetsky, M., Myamoto, C., Zippin, J.H., Kopf, G.S., Suarez, S.S., Levin, L.R.*, Williams, C.J.*, Buck, J.*, and Moss, S.B.* (2005). #145;Soluble' Adenylyl Cyclase mediates Multiple Specific Signaling Events in Sperm Required for Fertilization. Dev. Cell 9: 249-259.
  • Steegborn C, Litvin TN, Levin LR, Buck J, Wu H. (2005) Bicarbonate activation of adenylyl cyclase via promotion of catalytic active site closure and metal recruitment. Nature Struct Mol Biol. 12(1):32-7.
  • Zippin, J.H., Farrell, J., Huron, D., Kamenetsky, M., Hess, K.C., Fischman, D.A., Levin, L.R., and Buck, J. (2004). Bicarbonate responsive 'soluble' adenylyl cyclase defines a nuclear cAMP microdomain. J. Cell. Biol. 164:527-534.
  • Pastor-Soler, N., Beaulieu, V., Litvin, T.N., Da Silva, N., Chen, Y., Brown, D., Buck, J., Levin, L.R., and Breton, S. (2003). Bicarbonate regulated adenylyl cyclase (sAC) is a sensor that regulates pH-dependent V-ATPase recycling. J. Biol. Chem. 278:49523-49529.
  • Litvin, T.N., Kamenetsky, M., Zarifyan, A., Buck, J., and Levin, L.R. (2003). Kinetic Properties of 'soluble' adenylyl cyclase: synergism between calcium and bicarbonate. J. Biol. Chem. 278:15922-15926.
  • Zippin, J.H.*, Chen, Y.*, Nahirney, P.*, Kamenetsky, M., Wuttke, M.S., Fischman, D.A., Levin, L.R. and Buck, J. (2003). Compartmentalization of bicarbonate-sensitive adenylyl cyclase in distinct signaling microdomains. FASEB Journal 17: 82-84.
  • Zippin, J.H., Levin, L.R., and Buck, J. (2001). Bicarbonate/CO2 responsive soluble adenylyl cyclase as a putative metabolic sensor. Trends in Endocrinology & Metabolism 12: 366-370.
  • Chen, Y.*, Cann, M.J.*, Litvin, T.N., Iourgenko, V., Sinclair, M.L., Levin, L.R., and Buck, J. (2000). Soluble adenylyl cyclase as an evolutionarily conserved bicarbonate sensor. Science 289: 625-628.
  • Buck, J.*, Sinclair, M.L.*, Schapal, L. Cann, M.J., and Levin, L.R. (1999). Cytosolic adenylyl cyclase defines a unique signaling molecule in mammals. Proc. Natl. Acad. Sci. 96: 79-84.
  • Levin, L.R., Han, P.-L., Hwang, P.M., Feinstein, P.G., Davis, R.L., and Reed, R.R. (1992). The Drosophila learning and memory gene, rutabaga, encodes a Ca2 /Calmodulin-responsive adenylyl cyclase. Cell 68: 479-489.
  • Levin, L.R., Kuret, J., Johnson, K.E., Powers, S., Cameron, S., Michaeli, T., Wigler, M., and Zoller, M.J. (1988). A mutation in the catalytic subunit of cAMP-dependent protein kinase that disrupts regulation. Science 240: 68-70.
  • Other Publications

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