Publications
Howe LR & Brown PH (2011) Targeting the HER/EGFR/ErbB Family to Prevent Breast Cancer. Cancer Prevention Research, 4:1149-57
Subbaramaiah K, Howe LR, Bhardwaj P, Du B, Gravaghi C, Yantiss RK, Zhou XK, Blaho VA, Hla T, Yang P, Kopelovich L, Hudis CA & Dannenberg, A.J. (2011) Obesity is associated with inflammation and elevated aromatase expression in the mouse mammary gland. Cancer Prevention Research, 4:329-46.
Baker R, Kent CV, Silbermann RA, Hassell JA, Young LJT & Howe LR (2010) Pea3 Transcription Factors and Wnt1-Induced Mouse Mammary Neoplasia. PLoS ONE, 5:e8854. doi:10.1371/journal.pone.0008854.
Howe LR & Lippman SM (2008) Modulation of Breast Cancer Risk by Nonsteroidal Antiinflammatory Drugs. J. Natl Cancer Inst., 100:1420-3.
Brown PH, Subbaramaiah K, Salmon AP, Baker R, Newman RA, Yang P, Zhou XK, Bissonnette RP, Dannenberg AJ & Howe LR (2008) Combination chemoprevention of HER2/neu-induced breast cancer using a COX-2 inhibitor and an RXR-selective retinoid. Cancer Prevention Research, 1:208-14.
Girnum G, Howe LR, Manne, S, Mao, J, Reid M & Szabo E (2008) Meeting Report: Sixth Annual AACR Conference: Frontiers in Cancer Prevention Research. Cancer Prevention Research, 1:146-9.
Howe LR (2007) Rexinoids and Breast Cancer Prevention. Clinical Cancer Research, 13:5983-7.
Howe LR (2007) Cyclooxygenase/Prostaglandin Signaling in Breast Cancer. Breast Cancer Research, 9:210 (1-8).
Subbaramaiah K, Howe LR, Port ER, Brogi E, Fishman J, Liu CH, Hla T, Nithipatikom K, Hudis C, & Dannenberg AJ (2006) HER2/neu status is a determinant of mammary aromatase activity in vivo. Evidence for a COX-2-dependent mechanism. Cancer Research, 66:5504-11.
Howe LR (2005) Cyclooxygenase-2 and Breast Cancer. In: Yao, A.P., editor. Horizons in Cancer Research, Vol. 9, Trends in Breast Cancer Research, pp 1-38.
Howe LR, Chang S-H, Tolle KC, Dillon R, Young LJT, Cardiff RD, Newman RA, Yang P, Thaler HT, Muller WJ, Hudis C, Brown AMC, Hla T, Subbaramaiah K, & Dannenberg AJ (2005) HER2/neu-Induced Mammary Tumorigenesis and Angiogenesis Are Reduced in Cyclooxygenase-2 Knockout Mice. Cancer Research, 65:10113-9.
Peterlongo P, Howe LR, Radice P, Sala P, Hong Y-J, Hong S-I, Mitra N, Offitt K & Ellis NA (2005) Germline mutations of AXIN2 are not associated with nonsyndromic colorectal cancer. Human Mutation, 25:498-500.
Howe LR & Brown AMC (2004) Wnt Signaling and Breast Cancer. Cancer Biol. Ther., 3:36-41.
Brennan K, Gonzalez-Sancho JM, Castelo-Soccio LA, Howe LR & Brown AMC (2004) Truncated mutants of the putative Wnt receptor LRP6/Arrow can stabilize beta-catenin independently of Frizzled proteins. Oncogene, 23:4873-84.
Khan KMF, Howe LR & Falcone DJ (2004) Extracellular Matrix Induced Cyclooxygenase-2 Regulates Macrophage Proteinase Expression. J. Biol. Chem., 279:22039-46.
Dannenberg AJ & Howe LR (2003) The Role of COX-2 in Breast and Cervical Cancer. In: Dannenberg, A.J. & DuBois, R.N., editors. Progress in Experimental Tumor Research, Vol. 37, COX-2, A New Target for Cancer Prevention and Treatment. pp. 90-106.
Howe LR, Watanabe O, Leonard J, & Brown AMC (2003) Twist is upregulated in response to Wnt1 and inhibits mouse mammary cell differentiation. Cancer Research, 63:1906-13.
Howe LR & Dannenberg AJ (2003) COX-2 Inhibitors for the Prevention of Breast Cancer. J. Mamm. Gland Biol. & Neoplasia, 8:31-43.
Howe LR, Subbaramaiah K, Patel J, Masferrer JL, Deora A, Hudis C, Thaler HT, Muller WJ, Du B, Brown AMC & Dannenberg AJ (2002) Celecoxib, a selective cyclooxygenase-2 inhibitor, protects against human Epidermal Growth Factor Receptor 2 (HER-2)/Neu-induced breast cancer. Cancer Research, 62:5405-7.
Howe LR & Dannenberg AJ (2002) A Role for Cyclooxygenase-2 Inhibitors in the Prevention and Treatment of Cancer. Semin. Oncol., 3, Suppl. 11, 111-9.
Howe LR, Crawford HC, Subbaramaiah K, Hassell JA, Dannenberg AJ & Brown AMC (2001) PEA3 is upregulated in response to Wnt1 and activates the expression of cyclooxygenase-2. J. Biol. Chem., 276:20108-15.
Dannenberg AJ, Altorki NK, Boyle JO, Dang C, Howe LR, Weksler BB & Subbaramaiah K (2001) Cyclo#150;oxygenase-2: A Pharmacologic Target for the Prevention of Cancer. Lancet Oncology, 2:544-51.
Mackrell PJ, Daly JM, Mestre JR, Stapleton PP, Howe LR, Subbaramaiah K & Dannenberg AJ (2001) Elevated expression of cyclooxygenase-2 contributes to immune dysfunction in a murine model of trauma. Surgery, 130:826-833.
Howe LR, Subbaramaiah K, Brown AMC & Dannenberg AJ (2001) Cyclooxygenase-2: a target for the prevention and treatment of breast cancer. Endocrine-Related Cancer, 8:97-114.
Howe LR, Subbaramaiah K, Chung WJ, Dannenberg AJ & Brown AMC (1999) Transcriptional activation of cyclooxygenase-2 in Wnt-1-transformed mouse mammary epithelial cells. Cancer Research, 59:1572-7.
Howe LR & Weiss A (1995) Multiple kinases mediate T-cell-receptor signalling. Trends Biochem. Sci. 20:59-64.
Howe LR & Marshall CJ (1993) Lysophosphatidic acid stimulates mitogen-activated protein kinase activation via a G-protein-coupled pathway requiring p21ras and p74raf-1. J. Biol. Chem., 268:20717-20.
Marshall CJ, Ashworth A, Howe LR, Leevers SJ, Paterson HF, Thorneycroft SG, Gomez N, Nakielny S, Traverse S & Cohen P (1993) Activation of the MAP kinase pathway requires p21ras and p74raf-1. International Journal of Cancer, 53:171-2.
Schaap D, van der Wal J, Howe LR, Marshall CJ & van Blitterswijk WJ (1993) A dominant-negative mutant of raf blocks mitogen-activated protein kinase activation by growth factors and oncogenic p21ras. J. Biol. Chem., 268:20232-6.
Marshall CJ, Howe LR, Leevers SJ, Paterson HF & Thorneycroft SG (1993) Potential roles of p21ras in growth factor signalling - An overview. Mol. Oncol. & Clinical Applications 137-9.
Howe LR & Marshall CJ (1993) Identification of amino acids in p21ras involved in exchange factor interaction. Oncogene, 8:2583-90.
Howe LR, Leevers SJ, Gomez N, Nakielny S, Cohen P & Marshall CJ (1992) Activation of the MAP kinase pathway by the protein kinase raf. Cell, 71:335-42.
Hesketh TR, Metcalfe JC, Pennington SR & Howe LR (1990) Phosphoinositide metabolism in lymphocyte activation, in Mechanisms of leukocyte activation (Current topics in membranes and transport, Vol 35, eds. S. Grinstein and O.D. Rotstein) Academic Press.
Zilberman Y, Howe LR, Hesketh TR & Metcalfe JC (1987) Calcium regulates inositol 1,3,4,5-tetrakisphosphate production in lysed thymocytes and in intact cells stimulated with Concanavalin A. EMBO J. 6:957-62.
Wreggett KA, Howe LR, Moore JP & Irvine RF (1987) Extraction and recovery of inositol phosphates from tissues. Biochem J. 245:933-4.
