MOLECULAR AND BIOPHYSICAL APPROACHES TO UNDERSTANDING THE NERVOUS SYSTEM
Our lab is interested in synaptic function at the molecular and circuit levels. Formation and proper function of the nervous system depend critically on the operation of chemical synapses, which are the means by which neurons transmit information to one another. We study the molecules that underlie synaptic vesicle fusion and endocytosis in C. elegans using optical, genetic, and behavioral approaches. We are currently focused on two lines of research: spatial and temporal dynamics of synaptic proteins, and the role of neurotransmitter-gated GPCRs in modulating nervous system function.