Publications
Hochrainer, K., Racchumi, G., Zhang, S., Iadecola, C. & Anrather, J. Monoubiquitination of nuclear RelA negatively regulates NF-κB activity independent of proteasomal degradation. Cell. Mol. Life Sci. (2012).doi:10.1007/s00018-011-0912-2
Iadecola, C., Kahles, T., Gallo, E. F. & Anrather, J. Neurovascular protection by ischaemic tolerance: role of nitric oxide. J. Physiol. (Lond.) 589, 4137–4145 (2011).
Iadecola, C. & Anrather, J. The immunology of stroke: from mechanisms to translation. Nat. Med. 17, 796–808 (2011).
Zhou, P., Qian, L., Gallo, E. F., Deeb, R. S., Anrather, J., Gross, S. S. & Iadecola, C. The scavenger receptor CD36 contributes to the neurotoxicity of bone marrow-derived monocytes through peroxynitrite production. Neurobiol. Dis. 42, 292–299 (2011).
Park, L., Wang, G., Zhou, P., Zhou, J., Pitstick, R., Previti, M. L., Younkin, L., Younkin, S. G., Van Nostrand, W. E., Cho, S., Anrather, J., Carlson, G. A. & Iadecola, C. Scavenger receptor CD36 is essential for the cerebrovascular oxidative stress and neurovascular dysfunction induced by amyloid-beta. Proc. Natl. Acad. Sci. U.S.A. 108, 5063–5068 (2011).
Anrather, J., Gallo, E. F., Kawano, T., Orio, M., Abe, T., Gooden, C., Zhou, P. & Iadecola, C. Purinergic signaling induces cyclooxygenase-1-dependent prostanoid synthesis in microglia: roles in the outcome of excitotoxic brain injury. PLoS ONE 6, e25916 (2011).
Iadecola, C. & Anrather, J. Stroke research at a crossroad: asking the brain for directions. Nat. Neurosci. 14, 1363–1368 (2011).
Coleman, C. G., Wang, G., Park, L., Anrather, J., Delagrammatikas, G. J., Chan, J., Zhou, J., Iadecola, C. & Pickel, V. M. Chronic Intermittent Hypoxia Induces NMDA Receptor-Dependent Plasticity and Suppresses Nitric Oxide Signaling in the Mouse Hypothalamic Paraventricular Nucleus. J. Neurosci. 30, 12103–12112 (2010).
Abe, T., Shimamura, M., Jackman, K., Kurinami, H., Anrather, J., Zhou, P. & Iadecola, C. Key role of CD36 in Toll-like receptor 2 signaling in cerebral ischemia. Stroke 41, 898–904 (2010).
Capone, C., Faraco, G., Anrather, J., Zhou, P. & Iadecola, C. Cyclooxygenase 1-derived prostaglandin E2 and EP1 receptors are required for the cerebrovascular dysfunction induced by angiotensin II. Hypertension 55, 911–917 (2010).
Coleman, C. G., Anrather, J., Iadecola, C. & Pickel, V. M. Angiotensin II type 2 receptors have a major somatodendritic distribution in vasopressin-containing neurons in the mouse hypothalamic paraventricular nucleus. Neuroscience 163, 129–142 (2009).
Capone, C., Anrather, J., Milner, T. A. & Iadecola, C. Estrous cycle-dependent neurovascular dysfunction induced by angiotensin II in the mouse neocortex. Hypertension 54, 302–307 (2009).
Rodrigues, L., Filipe, J., Seldon, M. P., Fonseca, L., Anrather, J., Soares, M. P. & Simas, J. P. Termination of NF-κB activity through a gamma-herpesvirus protein that assembles an EC5S ubiquitin-ligase. EMBO J. 28, 1283–1295 (2009).
Girouard, H., Wang, G., Gallo, E. F., Anrather, J., Zhou, P., Pickel, V. M. & Iadecola, C. NMDA receptor activation increases free radical production through nitric oxide and NOX2. J. Neurosci. 29, 2545–2552 (2009).
Abe, T., Kunz, A., Shimamura, M., Zhou, P., Anrather, J. & Iadecola, C. The neuroprotective effect of prostaglandin E2 EP1 receptor inhibition has a wide therapeutic window, is sustained in time and is not sexually dimorphic. J. Cereb. Blood Flow Metab. 29, 66–72 (2008).
Kunz, A., Abe, T., Hochrainer, K., Shimamura, M., Anrather, J., Racchumi, G., Zhou, P. & Iadecola, C. Nuclear factor-κB activation and postischemic inflammation are suppressed in CD36-null mice after middle cerebral artery occlusion. J. Neurosci. 28, 1649–1658 (2008).
Park, L., Zhou, P., Pitstick, R., Capone, C., Anrather, J., Norris, E. H., Younkin, L., Younkin, S., Carlson, G., McEwen, B. S. & Iadecola, C. Nox2-derived radicals contribute to neurovascular and behavioral dysfunction in mice overexpressing the amyloid precursor protein. Proc. Natl. Acad. Sci. U.S.A. 105, 1347–1352 (2008).
Park, L., Gallo, E. F., Anrather, J., Wang, G., Norris, E. H., Paul, J., Strickland, S. & Iadecola, C. Key role of tissue plasminogen activator in neurovascular coupling. Proc. Natl. Acad. Sci. U.S.A. 105, 1073–1078 (2008).
Seldon, M. P., Silva, G., Pejanovic, N., Larsen, R., Gregoire, I. P., Filipe, J., Anrather, J. & Soares, M. P. Heme oxygenase-1 inhibits the expression of adhesion molecules associated with endothelial cell activation via inhibition of NF-κB RelA phosphorylation at serine 276. J. Immunol. 179, 7840–7851 (2007).
Park, L., Anrather, J., Girouard, H., Zhou, P. & Iadecola, C. Nox2-derived reactive oxygen species mediate neurovascular dysregulation in the aging mouse brain. J. Cereb. Blood Flow Metab. 27, 1908–1918 (2007).
Ruocco, A., Santillo, M., Cicale, M., Serù, R., Cuda, G., Anrather, J., Iadecola, C., Postiglione, A., Avvedimento, E. V. & Paternò, R. Farnesyl transferase inhibitors induce neuroprotection by inhibiting Ha-Ras signalling pathway. Eur. J. Neurosci. 26, 3261–3266 (2007).
Hochrainer, K., Racchumi, G. & Anrather, J. Hypo-phosphorylation leads to nuclear retention of NF-κB p65 due to impaired IκBα gene synthesis. FEBS Lett. 581, 5493–5499 (2007).
Orio, M., Kunz, A., Kawano, T., Anrather, J., Zhou, P. & Iadecola, C. Lipopolysaccharide induces early tolerance to excitotoxicity via nitric oxide and cGMP. Stroke 38, 2812–2817 (2007).
Kunz, A., Park, L., Abe, T., Gallo, E. F., Anrather, J., Zhou, P. & Iadecola, C. Neurovascular protection by ischemic tolerance: role of nitric oxide and reactive oxygen species. J. Neurosci. 27, 7083–7093 (2007).
Kawano, T., Kunz, A., Abe, T., Girouard, H., Anrather, J., Zhou, P. & Iadecola, C. iNOS-derived NO and Nox2-derived superoxide confer tolerance to excitotoxic brain injury through peroxynitrite. J. Cereb. Blood Flow Metab. 27, 1453–1462 (2007).
Girouard, H., Park, L., Anrather, J., Zhou, P. & Iadecola, C. Cerebrovascular Nitrosative Stress Mediates Neurovascular and Endothelial Dysfunction Induced by Angiotensin II. Arterioscler. Thromb. Vasc. Biol. 27, 303–309 (2006).
Wang, G., Anrather, J., Glass, M. J., Tarsitano, M. J., Zhou, P., Frys, K. A., Pickel, V. M. & Iadecola, C. Nox2, Ca2+, and protein kinase C play a role in angiotensin II-induced free radical production in nucleus tractus solitarius. Hypertension 48, 482–489 (2006).
Kunz, A., Anrather, J., Zhou, P., Orio, M. & Iadecola, C. Cyclooxygenase-2 does not contribute to postischemic production of reactive oxygen species. J. Cereb. Blood Flow Metab. 27, 545–551 (2006).
Girouard, H., Park, L., Anrather, J., Zhou, P. & Iadecola, C. Angiotensin II attenuates endothelium-dependent responses in the cerebral microcirculation through nox-2-derived radicals. Arterioscler. Thromb. Vasc. Biol. 26, 826–832 (2006).
Girouard, H., Park, L., Anrather, J., Zhou, P. & Iadecola, C. Angiotensin II attenuates endothelium-dependent responses in the cerebral microcirculation through nox-2-derived radicals. Arterioscler. Thromb. Vasc. Biol. 26, 826–832 (2006).
Anrather, J., Racchumi, G. & Iadecola, C. NF-κB regulates phagocytic NADPH oxidase by inducing the expression of gp91phox. J. Biol. Chem. 281, 5657–5667 (2006).
Park, E.-M., Cho, S., Frys, K. A., Glickstein, S. B., Zhou, P., Anrather, J., Ross, M. E. & Iadecola, C. Inducible nitric oxide synthase contributes to gender differences in ischemic brain injury. J. Cereb. Blood Flow Metab. 26, 392–401 (2006).
Kawano, T., Anrather, J., Zhou, P., Park, L., Wang, G., Frys, K. A., Kunz, A., Cho, S., Orio, M. & Iadecola, C. Prostaglandin E2 EP1 receptors: downstream effectors of COX-2 neurotoxicity. Nat. Med. 12, 225–229 (2006).
Cho, S., Park, E.-M., Febbraio, M., Anrather, J., Park, L., Racchumi, G., Silverstein, R. L. & Iadecola, C. The class B scavenger receptor CD36 mediates free radical production and tissue injury in cerebral ischemia. J. Neurosci. 25, 2504–2512 (2005).
Park, L., Anrather, J., Zhou, P., Frys, K., Pitstick, R., Younkin, S., Carlson, G. A. & Iadecola, C. NADPH-oxidase-derived reactive oxygen species mediate the cerebrovascular dysfunction induced by the amyloid beta peptide. J. Neurosci. 25, 1769–1777 (2005).
Anrather, J., Racchumi, G. & Iadecola, C. cis-acting element-specific transcriptional activity of differentially phosphorylated nuclear factor-κB. J. Biol. Chem. 280, 244–252 (2005).
