Biography
Major Research Interests:
Neurogenic regulations of hypertension
Angiotensin II-induced oxidative stress
Effects of naturally occurring medicines on CNS
Roles of voltage-gated ion channels in stimulation-secretion coupling
Education:
1983: M.D., Tongji Medical University, China
1988: Ph.D. Tongji Medical University, China
Research Experience:
2010-present : Associate Research Professor of Neuroscience, Department of Neurology & Neuroscience, Weill Cornell Medical College
1999-2009: Assistant Professor of Neuroscience, Department of Neurology & Neuroscience, Weill Cornell Medical College
1991-1998: Research Associate and Instructor, Department of Physiology, University of Massachusetts Medical School/Worcester Foundation
1988-1990: Visiting Doctor, Institute of Pharmacology & Toxicology, Technical University of Munich, Germany
1984-1987: Ph.D. candidate of Pharmacology, Department of Pharmacology, Tongji Medical College, China
Selected Publications:
Park L, Wang G, Zhou P, Zhou J, Pitstick R, Prevti ML, Younkin L, Younkin S, van Nostrand WE, Cho S, Anrather J, Carlson G and Iadecola C: The scavenger receptor CD36 is essential for the cerebrovascular oxidative stress and neurovascular dysfunction induced by amyloid-ß. Proc. Natl. Acad. Sci. USA 108:5063-5068, 2011.
Coleman CG, Wang G, Park L, Anrather J, Delagrammatikas GJ, Chan J, Zhou J, Iadecola C and Pickel VM:Chronic intermittent hypoxia induces NMDA receptor-dependent plasticity and suppresses nitric oxide signaling in the mouse hypothalamic paraventricular nucleus. J. Neurosci. 30:12103-12112, 2010.
Girouard H, Wang G, Zhou P, Anrather J and Iadecola C: NMDA receptor activation increases free radical production through nitric oxide and NOX2. J. Neurosci. 29:2545-2552, 2009.
Wang G, Milner TA, Speth RC, Gore AC, Wu D, Iadecola C and Pierce JP: Sex differences inangiontensin signaling in bulbospinal neurons in the rat rostral ventrolateral medulla. Am. J. Physiol. Regul. Integr. Comp. Physiol. 295:R1149-R1157, 2008.
Park L, Gallo EF, Anrather J, Wang G, Norris EH, Paul J, Strickland S and Iadecola C: Key role of tissue plasminogen activator in neurovascular coupling. Proc Natl Acad Sci USA. 105: 1073-1078, 2008.
Wang G: The Chapter: "Reactive oxygen species", In Schwartz M (Ed): Cancer Encyclopedia, 2nd Edition, Springer-Verlag, pp2559-2562, 2008.
Han X, Wang F, Yao W, Xing H, Weng D, Song X, Chen G, Xi L, Zhu T, Zhou J, Xu G, Wang S, Meng L, Iadecola C, Wang G and Ma D: Heat shock proteins and p53 play a critical role in K channel-mediated tumor cell proliferation and apoptosis. Apoptosis 12:1837-1846, 2007.
Kawano T, Anrather J, Zhou P, Park L, Wang G, Frys KA, Kunz A, Cho S, Orio M and Iadecola C: Prostaglandin E2 EP1 receptors: Downstream effectors of COX-2 neurotoxicity. Nat. Med. 12:225-229, 2006.
Wang G, Anrather J, Glass MJ, Tarsitano J, Zhou P, Frys KA, Pickel VM and Iadecola C: Nox2, Ca2 , and protein kinase C play a role in angiotensin II-induced free radical production in nucleus tractus solitarius. Hypertension 48:482-489, 2006.
Wang G, Lemos JR and Iadecola C: Herbal alkaloid tetrandrine: from an ion channel blocker to inhibitor of tumor proliferation. Trends Pharmacol. Sci. 25:120-123, 2004.
Wang G, Anrather J, Huang J, Speth RB, Pickel VM and Iadecola C: NADPH oxidase contributes to angiotensin II signaling in the nucleus tractus solitarius. J. Neurosci. 24: 5516-5524, 2004.
Kazama K, Wang G, Frys K, Anrather J & Iadecola C. (2003). Angiotensin II attenuates functional hyperemia in the mouse somatosensory cortex. American Journal of Physiology (Heart & Circulatory Physiology) 285: H1890-1899.
OuYang W, Wang G & Hemmings Jr. HC (2003). Isoflurane and propofol inhibit voltage-gated sodium channels in isolated rat neurohypophysial nerve terminals. Molecular Pharmacology 64: 373-381
Wang G, Gorbatyuk OS, Dayanithi G, Ouyany W, Wang JL, Miler TA, Regunathan S & Reis DJ (2002). Evidence for endogenous agmatine in hypothalamo-neurohypophysial tract and its modulation of vasopressin release and Ca2 channels. Brain Research 932:25-36
Wang G, Dayanithi G, Custer EE & Lemos JR (2002). Adenosine inhibition via the A1 receptor of N-type Ca2 current and peptide release from isolated neurohypophysial terminals of the rat. The Journal of Physiology (London) 540:791-802
Gorbatyuk OS, Milner TA, Wang G, Regunathan S & Reis DJ (2001). Localization of agmatine in vasopressin and oxytocin neurons of the rat hypothalamic paraventricular and supraoptic nuclei. Experimental Neurology 171:235-245
Lemos JR & Wang G (2000). Excitatory versus inhibitory modulation by ATP of neurohypophysial terminal activity in the rat. Experimental Physiology 85:67S-74S
Dopico AM, Widmer H, Wang G, Lemos JR & Treistman SN (1999). Rat supraoptic magnocellular neurons show distinct large conductance, Ca2 -activated K channel subtypes in cell bodies versus nerve endings. The Journal of Physiology (London) 519:101-114
Wang G, G Dayanithi, R Newcomb & JR Lemos (1999). An R-type Ca2 current in neurohypophysial terminals preferentially regulates oxytocin secretion. The Journal of Neuroscience 19:9235-9241
Newcomb R, Szoke B, Palma A, Wang G, Chen XH, Hopkins W, Cong R, Meller J, Urge L, Tarczy-Hornoch K, Loo JA, Dooley DJ, Nadasdi L, Tsien RW, Lemos JR & Miljanich G (1998). Selective peptide antagonist of the class E calcium channel from the venom of the tarantuala Hysterocrates gigas. Biochemistry 37:15353-15362
Wang G, Dayanithi G, Stuenkel E, Hom D, Nadasdi L, Kristipati R, Nordmann JJ, Ramachandran J, Newcomb R & Lemos JR (1997). Role of Q-type Ca2 channels in vasopressin secretion from neurohypophysial terminals of the rat. The Journal of Physiology (London) 502:351-363
Wang G & Lemos JR (1995). Tetrandrine: a new ligand to block voltage-dependent Ca2 and Ca2 -activated K channels (Review). Life Sciences 56:295-306 (Review)
Wang XM, Wang G, Lemos JR & Treistman SN (1994). Ethanol modulates gating of a dihydropyri-dine-sensitive Ca2 channel in neurohypophysial terminals. The Journal of Neuroscience 14:5453-5460
Wang G, Thorn P & Lemos JR (1992). A novel large-conductance Ca2 -activated potassium channel and current in nerve terminals of the rat neurohypophysis. The Journal of Physiology (London) 457:47-74
Wang G & Lemos JR (1992). Tetrandrine blocks a slow, large-conductance, Ca2 -activated potassium channel besides inhibiting a non-inactivating Ca2 current in isolated nerve terminals of the rat neurohypophysis. Pflügers Archives-Journal of European Physiology 421:558-565
Wang G, Dugas M, Armah BI & Honerjaeger P (1990). Interaction between DPI 201-106 enantiomers at the cardiac sodium channel. Molecular Pharmacology 37:17-24
Wang G, Dugas M, Armah BI & Honerjaeger P (1990). Sodium channel comodification with full activator reveals veratridine reaction dynamics. Molecular Pharmacology 37:144-148
