Biography
Major Research Interests:
Neurogenic regulations of circulations
Hypoxia-induced oxidative stress
Effects of naturally occurring medicines on CNS
Roles of voltage-gated ion channels in stimulation-secretion coupling
Education:
1983: M.D., Tongji Medical University, China
1988: Ph.D. Tongji Medical University, China
Research Experience:
1999-present: Assistant Professor of Neuroscience, Department of Neurology & Neuroscience, Weill Medical College of Cornell University
1991-1998: Research Associate and Instructor, Department of Physiology, University of Massachusetts Medical School and Worcester Foundation
1988-1990: Visiting Doctor, Institute of Pharmacology & Toxicology, Technical University of Munich, Germany
1984-1987: Ph.D. candidate of Pharmacology, Department of Pharmacology, Tongji Medical College, China
Selected Publications:
Wang G, Lemos JR & Iadecola C. (2004) Herbal alkaloid tetrandrine: from an ion channel blocker to suppressor of tumor proliferation. Trends in Pharmacological Sciences 25(3):120-123 (Review).
Kazama K, Wang G, Frys K, Anrather J & Iadecola C. (2003). Angiotensin II attenuates functional hyperemia in the mouse somatosensory cortex. American Journal of Physiology (Heart & Circulatory Physiology) 285: H1890-1899.
OuYang W, Wang G & Hemmings Jr. HC (2003). Isoflurane and propofol inhibit voltage-gated sodium channels in isolated rat neurohypophysial nerve terminals. Molecular Pharmacology 64: 373-381
Wang G, Gorbatyuk OS, Dayanithi G, Ouyany W, Wang JL, Miler TA, Regunathan S & Reis DJ (2002). Evidence for endogenous agmatine in hypothalamo-neurohypophysial tract and its modulation of vasopressin release and Ca2 channels. Brain Research 932:25-36
Wang G, Dayanithi G, Custer EE & Lemos JR (2002). Adenosine inhibition via the A1 receptor of N-type Ca2 current and peptide release from isolated neurohypophysial terminals of the rat. The Journal of Physiology (London) 540:791-802
Gorbatyuk OS, Milner TA, Wang G, Regunathan S & Reis DJ (2001). Localization of agmatine in vasopressin and oxytocin neurons of the rat hypothalamic paraventricular and supraoptic nuclei. Experimental Neurology 171:235-245
Lemos JR & Wang G (2000). Excitatory versus inhibitory modulation by ATP of neurohypophysial terminal activity in the rat. Experimental Physiology 85:67S-74S
Dopico AM, Widmer H, Wang G, Lemos JR & Treistman SN (1999). Rat supraoptic magnocellular neurons show distinct large conductance, Ca2 -activated K channel subtypes in cell bodies versus nerve endings. The Journal of Physiology (London) 519:101-114
Wang G, G Dayanithi, R Newcomb & JR Lemos (1999). An R-type Ca2 current in neurohypophysial terminals preferentially regulates oxytocin secretion. The Journal of Neuroscience 19:9235-9241
Newcomb R, Szoke B, Palma A, Wang G, Chen XH, Hopkins W, Cong R, Meller J, Urge L, Tarczy-Hornoch K, Loo JA, Dooley DJ, Nadasdi L, Tsien RW, Lemos JR & Miljanich G (1998). Selective peptide antagonist of the class E calcium channel from the venom of the tarantuala Hysterocrates gigas. Biochemistry 37:15353-15362
Wang G, Dayanithi G, Stuenkel E, Hom D, Nadasdi L, Kristipati R, Nordmann JJ, Ramachandran J, Newcomb R & Lemos JR (1997). Role of Q-type Ca2 channels in vasopressin secretion from neurohypophysial terminals of the rat. The Journal of Physiology (London) 502:351-363
Wang G & Lemos JR (1995). Tetrandrine: a new ligand to block voltage-dependent Ca2 and Ca2 -activated K channels (Review). Life Sciences 56:295-306 (Review)
Wang XM, Wang G, Lemos JR & Treistman SN (1994). Ethanol modulates gating of a dihydropyri-dine-sensitive Ca2 channel in neurohypophysial terminals. The Journal of Neuroscience 14:5453-5460
Wang G, Thorn P & Lemos JR (1992). A novel large-conductance Ca2 -activated potassium channel and current in nerve terminals of the rat neurohypophysis. The Journal of Physiology (London) 457:47-74
Wang G & Lemos JR (1992). Tetrandrine blocks a slow, large-conductance, Ca2 -activated potassium channel besides inhibiting a non-inactivating Ca2 current in isolated nerve terminals of the rat neurohypophysis. Pflügers Archives-Journal of European Physiology 421:558-565
Wang G, Dugas M, Armah BI & Honerjaeger P (1990). Interaction between DPI 201-106 enantiomers at the cardiac sodium channel. Molecular Pharmacology 37:17-24
Wang G, Dugas M, Armah BI & Honerjaeger P (1990). Sodium channel comodification with full activator reveals veratridine reaction dynamics. Molecular Pharmacology 37:144-148
