David J. Christini, Ph.D.

• Research
• Honors & Awards
• Biography
• Publications

Publications

1.      Christini DJ, Bennett FM, Lutchen KR, Ahmed HM, Hausdorff JM, and Oriol N, “Application of linear and nonlinear time series modeling to heart rate dynamics analysis” IEEE Trans. on Biomedical Engineering, 42, pp. 411-415 (1995).

2.      Christini DJ, Kulkarni A, Rao S, Stutman ER, Bennett FM, Hausdorff JM, Oriol N, and Lutchen KR, "Influence of autoregressive model parameter uncertainty on spectral estimates of heart rate dynamics," Annals of Biomedical Engineering, 23, pp. 127-134 (1995).

3.      Christini DJ and Collins JJ, "Controlling non-chaotic neuronal noise using chaos control techniques," Physical Review Letters, 75:2782-2785 (1995).

4.      Christini DJ and Collins JJ, "Using noise and chaos control to control nonchaotic systems," Physical Review E, 52, pp. 5806-5809 (1995).

5.      Christini DJ and Collins JJ, "Using chaos control and tracking to suppress a pathological nonchaotic rhythm in a cardiac model," Physical Review E, 53:R49-R52 (1996).

6.      Christini DJ, Collins JJ, and Linsay PS, "Experimental control of high-dimensional chaos: The driven double pendulum," Physical Review E, 54, pp. 4824-4827 (1996).

7.      Hall K, Christini DJ, Tremblay M, Collins JJ, Glass L, and Billette J, "Dynamic control of cardiac alternans," Physical Review Letters, 78:4518-4521 (1997).

8.      Christini DJ and Collins JJ, "Real-time, adaptive, model-independent control of low-dimensional chaotic and nonchaotic dynamical systems," IEEE Transactions on Circuits and Systems-I, 44, pp. 1027-1030 (1997).

9.      Christini DJ and Collins JJ, "Control of chaos in excitable physiological systems: A geometric analysis," CHAOS, 7:544-549; doi:10.1063/1.166279 (1997).

10.  Christini DJ, In V, Spano ML, Ditto WL, and Collins JJ, "Real-time experimental control of a system in its chaotic and nonchaotic regimes," Physical Review E, 56:R3749-R3752 (1997).

11.  Christini DJ, Stein KM, Markowitz SM, and Lerman BB, "Practical real-time computing system for biomedical experiment interface," Annals of Biomedical Engineering, 27:180-186 (1999).

12.  Christini DJ and Kaplan DT, "Adaptive estimation and control method for unstable periodic dynamics in spike trains," Physical Review E, 61:5149-5153 (2000).

13.  Hall K and Christini DJ, "Restricted feedback control of one-dimensional maps," Physical Review E, 63:046204-1 – 046204-9; doi:10.1103/PhysRevE.63.046204 (2001).

14.  Christini DJ, Walden J, and Edelberg JM, "Direct biologically-based biosensing of dynamic physiological function," American Journal of Physiology, 280:H2006-H2010 (2001).

15.  Dorval AD, Christini DJ, and White JA, "Real-Time Linux Dynamic Clamp: A fast and flexible way to construct virtual ion channels in living cells," Annals of Biomedical Engineering, 29:897-907; doi:10.1114/1.1408929 (2001).

16.  Christini DJ, Stein KM, Markowitz SM, Mittal S, Slotwiner DJ, Iwai S, and Lerman BB, “Complex AV-nodal dynamics during ventricular-triggered atrial pacing in humans,” American Journal of Physiology, 281:H865-H872 (2001).

17.  Christini DJ, Stein KM, Markowitz SM, Mittal S, Slotwiner DJ, Scheiner MA, Iwai S, and Lerman BB, "Nonlinear-dynamical arrhythmia control in humans," Proceedings of the National Academy of Sciences, 98:5827-5832; doi:10.1073/pnas.091553398 (2001).

18.  Edelberg JM, Jacobson JT, Gidseg DS, Tang L, and Christini DJ, "Enhanced myocyte-based biosensing of the blood-borne signals regulating chronotropy," Journal of Applied Physiology, 92:581-585; doi:10.1152/japplphysiol.00672.2001 (2002).

19.  Sinha S, Stein KM, and Christini DJ, "Critical role of inhomogeneities in pacing termination of cardiac reentry," Chaos, 12:893-902; doi:10.1063/1.1501176 (2002).

20.  Sinha S and Christini DJ, "Termination of reentry in an inhomogeneous ring of model cardiac cells," Physical Review E, 66:061903-1 – 061903-7; doi:10.1103/PhysRevE.66.061903 (2002).

21.  Slotwiner DJ, Christini DJ, Stein KM, Markowitz SM, Mittal S, Iwai S, Das M, and Lerman BB, "Muscle sympathetic nerve traffic during spontaneous vs. adenosine-mediated termination of idiopathic right ventricular outflow tract tachycardia," American Journal of Cardiology, 91: 86-88; doi:10.1016/S0002-9149(02)03006-0 (2003).

22.  Tang L, Christini DJ, and Edelberg JM, "Genetically engineered biologically based hemostatic bioassay," Annals of Biomedical Engineering, 31:159-162; doi:10.1114/1.1537693 (2003).

23.  McCrossan ZA, Lewis A, Panaghie G, Jordan PN, Christini DJ, Lerner DJ, and Abbott GW, "MinK-related peptide 2 modulates Kv2.1 and Kv3.1 potassium channels in mammalian brain," Journal of Neuroscience, 23:8077-8091 (2003).

24.  Christini DJ, Stein KM, Hao SC, Markowitz SM, Mittal S, Slotwiner DJ, Iwai S, Das MK, and Lerman BB, "Endocardial detection of repolarization alternans," IEEE Transactions on Biomedical Engineering, 50:855-862; doi:10.1109/TBME.2003.813535 (2003).

25.  Gong Y and Christini DJ, "Antispiral waves in reaction-diffusion systems," Physical Review Letters, 90:088302-1 – 088302-4; doi:10.1103/PhysRevLett.90.088302 (2003).

26.  Hao SC, Christini DJ, Stein KM, Jordan PN, Iwai S, Bramwell O, Markowitz SM, Mittal S, and Lerman BB, “Effect of beta adrenergic blockade on dynamic electrical restitution in vivo,” American Journal of Physiology 287:H390-H394; doi:10.1152/ajpheart.00749.2003 (2004).

27.  Jordan PN and Christini DJ, "Determining the effects of memory and action potential duration alternans on cardiac restitution using a constant-memory restitution protocol", Physiological Measurement 25:1013-1024; doi:10.1088/0967-3334/25/4/018 (2004).

28.  Markowitz SM, Christini DJ, Stein KM, Mittal S, Iwai S, Slotwiner DJ, and Lerman BB, “Time course and predictors of autonomic dysfunction after ablation of the slow atrioventricular nodal pathway,” Pacing and Clinical Electrophysiology 27:1638-1643 (2004).

29.  Jordan PN and Christini DJ, "Adaptive diastolic interval control of cardiac action potential duration alternans," Journal of Cardiovascular Electrophysiology 15:1177-1185; doi:10.1046/j.1540-8167.2004.04098.x (2004).

30.  Gong Y and Christini DJ, "Functional reentrant waves propagate outwardly in cardiac tissue," Physics Letters A 331:209-216; doi:10.1016/j.physleta.2004.09.004 (2004).

31.  Maybhate A, Hao SC, Iwai S, Lee JU, Guttigoli AB, Stein KM, Lerman BB, and Christini DJ, "Detection of repolarization alternans with an implantable cardioverter defibrillator lead in a porcine model," IEEE Transactions on Biomedical Engineering, 52:1188-1194; doi:10.1109/TBME.2005.847537 (2005).

32.  Jordan PN and Christini DJ, "Action potential morphology influences intracellular calcium handling stability and the occurrence of alternans," Biophysical Journal, 90:672-680; doi:10.1529/biophysj.105.071340 (2006).

33.  Christini DJ, Riccio ML, Culianu CA, Fox JJ, Karma A, and Gilmour RF Jr., "Control of electrical alternans in canine cardiac Purkinje fibers," Physical Review Letters, 96:104101-1 – 104101-4; doi:10.1103/PhysRevLett.96.104101 (2006).

34.  Krogh-Madsen T and Christini DJ, “APD dispersion and alternans in simulated heterogeneous cardiac tissue with a structural barrier,” Biophysical Journal, 92:1138-1149; doi:10.1529/biophysj.106.090845 (2007).

35.  Gong Y, Xie F, Stein KM, Garfinkel A, Culianu CA, Lerman BB, Christini DJ, “General mechanism underlying initiation of paroxysmal atrial flutter/atrial fibrillation by ectopic foci – A simulation study,” Circulation, 115:2094-2102; doi:10.1161/circulationaha.106.656504 (2007).

36.  Jordan PN and Christini DJ, “Characterizing the contribution of voltage- and calcium-dependent coupling to action potential stability: Implications for repolarization alternans,” American Journal of Physiology, 293:H2109-H2118; doi:10.1152/ajpheart.00609.2007 (2007).

37.  Iravanian S and Christini DJ, “Optical mapping system with real-time control capability,” American Journal of Physiology, 293:H2605-H2611; doi:10.1152/ajpheart.00588.2007 (2007).

38.  Gordon E, Panaghie G, Deng L, Bee KJ, Roepke TK, Krogh-Madsen T, Christini DJ, Ostrer H, Basson CT, Chung W, and Abbott GW, "A KCNE2 mutation in a patient with cardiac arrhythmia induced by auditory stimuli and serum electrolyte imbalance," Cardiovascular Research, 77:98-106; doi:10.1093/cvr/cvm030 (2008).

39.  Roepke TK, Kontogeorgis A, Ovanez C, Xu X, Young JB, Purtell K, Goldstein PA, Christini DJ, Peters NS, Akar, FG, Gutstein DE, Lerner DJ, and Abbott GW, “Targeted deletion of kcne2 impairs ventricular repolarization via disruption of

40.  I_K,slow1 and I_to,f,” FASEB J., 22:3648-3660; doi:10.1096/fj.08-110171 (2008).

41.  Krogh-Madsen T and Christini DJ, "Resetting and termination of reentry in a loop-and-tail cardiac model," Physical Review E, 77:011916-1 – 011916-5; doi:10.1103/PhysRevE.77.011916 (2008).

42.  Xu X, Kanda VA, Choi E, Panaghie G, Roepke TK, Gaeta SA, Christini DJ, Lerner DJ and Abbott GW, "MinK-dependent internalization of the I_Ks potassium channel," Cardiovascular Research, 82:430-438; doi:10.1093/cvr/cvp047 (2009).

43.  Ahrens-Nicklas RC, Clancy CE, Christini DJ, “Re-evaluating the efficacy of beta-adrenergic agonists and antagonists in long QT-3 syndrome through computational modeling,” Cardiovascular Research, 82:439-447; doi:10.1093/cvr/cvp083 (2009).

44.  Maoz A, Krogh-Madsen T, and Christini DJ, "Instability in action potential morphology underlies phase-2 reentry – A mathematical modeling study," Heart Rhythm, 6:813-822; doi:10.1016/j.hrthm.2009.02.043 (2009).