LABORATORY FOR ADVANCES MRS RESEARCH
Current research in our laboratory focuses on the development of advanced magnetic resonance spectroscopy (MRS) and imaging (MRI) methods for application to clinical and biomedical research. Our goal is to develop noninvasive and objective MRI and MRS biomarkers of neurological, neuropsychiatric and metabolic disorders that would advance our understanding of their pathphysiology, facilitate their diagnosis and enable monitoring of their response to established or emerging therapeutic interventions. Examples of current projects include MRS measurements of levels of the neurotransmitters gamma-aminobutyric acid (GABA) and glutamate in pediatric and adult depression and in schizophrenia. We are also using MRS to measure brain lactic acid, the antioxidant glutathione (GSH), several high-energy phosphates (e.g. ATP, PCr), and other metabolites in chronic fatigue syndrome (CFS), Lou Gehrig's disease (ALS), mitochondrial disorders, Parkinson’s disease, and brain and breast cancers.