Publications
Sung, C-H., Hu, C.-P., Hsu, H.-C., Ng, A. K., Chou, C.-K., Ting, L. P., Su, T.-S., Han, S., and Chang, C. 1989. Expression of class I and class II major histocompatibility antigens on human hepatocellular carcinoma. J. Clin. Invest. 83: 421-429.
Sung, C.-H., Davenport, C. M., Hennessey, J. C., Maumenee, I. H., Jacobson, S. G., Heckenlively, J. R., Nowakowski, R., Fishman, G., Gouras, P., & Nathans, J. 1991. Rhodopsin mutations in autosomal dominant retinitis pigmentosa. Proc. Natl. Acad. Sci. USA 88: 6481-6485.
Sung C.-H., Schneider, B., Agarwal, N., Papermaster, D. S., and Nathans, J. 1991. Functional heterogeneity of mutant rhodopsins responsible for autosomal dominant retinitis pigmentosa. Proc. Natl. Acad. Sci. USA 88: 8840-8844.
Jacobson, S. G., Kemp, C. M., Sung, C.-H., and Nathans, J. 1991. Retinal function and rhodopsin levels in autosomal dominant retinitis pigmentosa with rhodopsin mutations. Am. J. Ophthalmol. 112: 256-271.
Kemp, C. M., Jacobson, S. G., Roman, A. J., Sung, C.-H., and Nathans, J. 1992. Abnormal rod dark adaptation in autosomal dominant retinitis pigmentosa with proline-23-histidine rhodopsin mutation. Am. J. Ophthalmol. 113: 165-174.
Nathans, J., Sung, C.-H., Weitz, C. J., Davenport, C. M., Merbs, S. L., and Wang, Y. 1992. Visual pigments and inherited variation in human vision. J. Gen. Physiol.-Sensory Transduction, 110-131.
Nathans, J., Merbs, S. L., Sung, C.-H., Weitz, C. J., and Wang, Y. 1992. Molecular genetics of human visual pigments. Anna. Rev. of Genetics 26: 403-424.
Sung, C.-H., Davenport C., and Nathans, J. 1993. Rhodopsin mutations responsible for autosomal dominant retinitis pigmentosa: clustering of functional classes along the polypeptide chain. J. Biol. Chem. 268: 26645-26649.
Portera-Cailliau, C., Sung, C.-H., Nathans, J., and Adler, R. 1994. Apoptotic photoreceptor cell death in mouse models of retinitis pigmentosa. Proc. Natl. Acad. Sci. USA 91: 974-978.
Jacobson, S. G., Kemp, C. M., Cideciyan, A. V., Macke, J. P., Sung, C.-H., and Nathans, J. 1994. Phenotypes of stop codon and splice site rhodopsin mutations causing retinitis pigmentosa. Invest. Ophthal. Vis. Science. 35: 2521-2534.
Sung, C.-H., Makino, C., Baylor, D., and Nathans, J. 1994. A rhodopsin gene mutation responsible for autosomal dominant retinitis pigmentosa results in a protein that is defective in localization to the photoreceptor outer segment. J. Neurosci. 14: 5818-5833.
Kumar, R., Chen, S., Scheurer, D., Duh, E., Sung, C.-H., Rehemtulla, A., Swaroop, A., Adler, R., and Zack, D. J. 1996. The bZIP transcription factor Nrl stimulates rhodopsin promoter activity in primary retinal cell cultures. J. Biol. Chem. 2271: 29612-29618.
La Vail, M. M., Yasumura, D., Matthes, M. T., Lau-Villacorta, C., Unoki, K., Sung, C.-H., and Steinberg, R. H. 1998. Protection of mouse photoreceptors by survival factors in retinal degenerations. Invest. Ophthal. Vis. Science 39:592-602.
Tai, A. W., J.-Z. Chuang, and C.-H. Sung. 1998. Localization of Tctex-1, a cytoplasmic dynein light chain, to the Golgi apparatus and evidence for dynein complex heterogeneity. J. Biol. Chem. 273: 19639-19649.
Chuang, J.-Z., and C.-H. Sung. 1998. The carboxy-terminus of rhodopsin functions as an apical sorting signal in MDCK cells. J. Cell Biol. 142: 1245-1256.
Chuang, J.-Z., T. A. Milner, M. Zhu, and C.-H. Sung. 1999. A 29 kDa intracellular chloride channel p64H1 is associated with large-dense core vesicles in rat hippocampal neurons. J. Neurosci. 19:2919-2928.
Sung C-H, and J. -Z. Chuang. 1999. The cytoplasmic tail of rhodopsin acts as an apical sorting signal in MDCK cells and photoreceptors. In Retinal Degenerative Diseases and Experimental Therapy (Hollyfield J. G., Anderson R. E. and LaVail M. M., eds.), pp 129-144. Plenum Publishing Co., New York.
Tai, A. W., J.-Z. Chuang, C. Bode, U. Wolfrum, and C.-H. Sung. 1999. Rhodopsin's carboxy-terminal cytoplasmic tail acts as a membrane receptor for cytoplasmic dynein by binding to the dynein light chain Tctex-1. Cell 97: 877-887.
Sung, C.-H. and A. W. Tai. 2000. Rhodopsin trafficking and its role in retinal dystrophy. International Review of Cytology 195: 215-267.
Yano, H. F. Lee, H. Kong, J. C. Arevalo, P. Perez, C.-H. Sung, and M. V. Chao. 2001. Association of a component of the cytoplasmic dynein motor with the Trk neurotrophin receptor. J. Neurosci. 21: RC125(1-7).
Tai, A. W., J.-Z. Chuang, and C.-H. Sung. 2001. Cytoplasmic dynein function is regulated by its subunit composition and is required for the apical translocation of rhodopsin in polarized MDCK cells. J. Cell Biol. 153:1499-1509.
Chuang, J.-Z. T. A. Milner, and C.-H. Sung. 2001. Subunit heterogeneity of cytoplasmic dynein: differential expression of 14-kDa dynein light chains in rat hippocampus. J. Neurosci. 21:5501-5512.
Yamada, H., Yamada, E., Ando, A., Esumi, N., Bora, N., J. Saikia, J., Sung, C.-H., D. Zack,. and Campochiaro, P. A. 2001. Fibroblast growth factor-2 decreases hyperoxia-induced photoreceptor cell death in mice. Am. J. Histopath. 159: 1113-1120.
Chuang, J.-Z., H. Zhou, M. Zhu, S.-H. Li, X.-J. Li, C.-H. Sung. 2002. Characterization of a brain-enriched chaperone, MRJ, that inhibits huntingtin aggregation and toxicity independently. J. Biol. Chem. 277:19831-19838.
Dunaief, J. L., A. King, N. Esumi, M. Eagen, T. Dentchev, C.-H. Sung, S. Chen, and D. J. Zack. 2002. Protein Phosphatase 1 binds strongly to the retinoblastoma protein but not to p107 or p130 in vitro and in vivo. 2002. Curr. Eye Res. 24:392-396
Wang. X., S. Xu., C. Rivolta, L. Li, G.-H. Peng, P.-K. Swain, C.-H. Sung, A. Swaroop, E. L. Berson, T. P. Dryja, R. Craigie, and S. Chen. 2002. Barrier to autointegration factor interacts with the cone-rod homeobox and represses its transactivation function. J. Biol. Chem. 277:43288-43300.
Hu Y, J.-Z. Chuang, K. Xu, T. G. McGraw, C.-H. Sung. 2002. SARA, a FYVE domain protein, affects Rab5-mediated endocytosis. 2002. J. Cell Sci. 115:4755-4763.
Sung, C.-H. and J.-Z. Chuang. 2004. Cytoplasmic dynein-mediated photoreceptor protein transport. In Cell Biology and Related Disease of the Outer Retina (Williams, D. eds). World Scientific Co.
Chuang, J.-Z., C. Vega, W. Jun, and C.-H. Sung. 2004. Structural and functional impairment of endocytic pathways by retinitis pigmentosa mutant rhodopsin-arrestin complexes. J. Clin. Invest. 114(1):131-140. (COVER)
Yeh, T., J.-Z. Chuang, C.-H. Sung. 2005. Cytoplasmic dynein light chain RP3 is a nuclear matrix associated transcription co-repressor. J. Cell Sci. 118:3431-3443 (COVER).
Chuang, J.-Z., T.-Y Yeh, C. Conde, F. Canavosio, F. Bollati, A. Caceres, and C.-H. Sung. 2005. Tctex-1 has a dynein-independent role in actin remodeling in neurite outgrowth. Developmental Cell 9: 75-85 (COVER).
Dedesma, C., Chuang, J.-Z., Alfinito, P., and C.-H. Sung. 2006. Dynein light chain Tctex-1 identifies neural progenitors in adult brain. J. Comp. Neurol. 496: 773-786.
Yeh, T.-Y. D. Peretti, J.-Z. Chuang, E. Rodriguez-Boulan, and C.-H. Sung. 2006. Regulatory dissociation of Tctex-1 light chain from dynein complex is essential for the apical delivery of rhodopsin. Traffic 7: 1495-1502.
Sachdev, P, Menon, S., Kastner, D. B., Chuang, J.-Z., Yeh, T-Y., Conde, C., Caceres, A., Sung, C-H., and Sakmar, T. P. 2007. G protein ?? subunit interaction with the dynein light-chain component Tctex-1 regulates neurite outgrowth. The EMBO Journal 26, 2621#150;2632.
Chuang, J.-Z., Zhao, Y, and Sung, C.-H. 2007. SARA-regulated vesicular targeting underlies formation of the light sensing organelle in mammalian rods. Cell 130:535-547 (COVER).
Alpadi, K., Magupalli, V.G., Kaeppel S., Köblitz, L., Schwarz, K., Seigel, G. M., Sung, C.-H., and Schmitz, F. RIBEYE recruits Munc119, a mammalian ortholog of the C. elegans protein unc119, to synaptic ribbons of photoreceptor synapses (J. Biol. Chem. 2008.Jul 29. [Epub ahead of print])
Martín-Cófreces, N.B., Robles-Valero, J., Cabrero, J. M., Mittelbrunn, M., Gordón-Alonso, M., Sung, C.-H., Alarcón, B., Vázquez, J., and Sánchez #150;Madrid, F. 2008. MTOC translocation modulates IS formation and controls sustained T cell signaling. J. Cell Biol. 182: 951-962.
Conde C, Arias C, Li A, Chuang J-Z, Sung C.-H., Cáceres A. 2010. Evidence for the involvement of Lfc and Tctex-1 in axon formation. J. Neurosci 30:6793-6800.
Venkatesan,J.K., Natarajan,S., Schwarz,K., Mayer, S.I., Alpadi,K.,Magupalli, V.G., Sung, C.-H., and F.Schmit. Nicotinamide Adenine Dinucleotide-Dependent Binding of the Neuronal Ca2 Sensor Protein GCAP2 to Photoreceptor Synaptic Ribbons. 2010. J. Neurosci., 30: 6559-6576.
Tseng, Y.-Y., Gruzdeva, N., Li, A., Chuang, and J.-Z., Sung, C.-H. 2010. Identification of the Tctex-1 regulatory element that directs expression to neural stem/progenitor cells in developing and adult brain. J. Comp. Neurol. 518:3327-3342. PMCID: PMC2899893
J.-Z. Chuang, Chou, S.-Y., and Sung, C.-H.2010. Chloride intracellular channel 4 is critical for the epithelial morphogenesis of RPE cells and retinal attachment. Mol Biol Cell 21:3017-3028 (COVER). Highlight of Editor's Choice.
Pavlos, N. J., Xu, J., Feng, H.-T., Ng, P.-Y., Ang, E.S., Carrello, A., Eidne, K.A., Sung, C.-H., Jahn, R., Zheng, M.-H. 2011. Identification of cytoplasmic dynein light chain protein Tctex-1 as a binding partner for Rab3GTPase. Mol. Cell Bio.31:1551-1564.
He, G., Ma, Y., Chou, S.-Y., Li. H., Yang, C., Chuang, J.-Z., Sung, C.-H., and A. Ding. A. Role of CLIC4 in LPS-induced IRF3 activation in macrophages. Eu. J. Immunol 41:1221-1230. PMC Journal-In Process.
Li, A., Saito, M., Chuang, J.-Z., Tseng, Y.-Y., Dedesma, C., Tomizawa, K., Kaitsuka, T., and C.-H. Sung. 2011. Ciliary base activation of phospho-Tctex-1 controls ciliary resorption, S-phase re-entry and neural stem cell self-renewal. Nat Cell Biol. 2011. 13:402-11. PMID: 21394082; PMC Journal-In Process. Featured by Commentary in Nature Cell Biology.
Li A and Sung, C.-H. Ciliary resorption modulates the G1 length and cell cycle progression. 2011. Cell Cycle 10: 2825-2826. PMID: 21964298; PMC Journal-In Process.
Pearson R.A., Barber A.C., Rizzi M., Hippert C., Xue T., West, E.L., Duran Y., Smith A.J., Chuang J.Z., Azam S.A., Luhmann U.F.O., Benucci A., Sung C.H., Yau K.W., Carandini M., Sowden J.C., Ali, R.R. 2012. Restoration of vision following transplantation of photoreceptors. Nature. 2012 485:99-103. PMID: 22522934
