Anjali M. Rajadhyaksha, Ph.D.

• Research
• Biography
• Publications

Publications

Rajadhyaksha AM, Ra S, Kishinevsky S, Lee AS, Romanienko P, Duboff M, Yang C, Zupan B, Byrne M, Daruwalla ZR, Mark W, Kosofsky BE, Toth M, Higgins JJ. (2012) Behavioral characterization of cereblon forebrai-specific conditional null mice: A model for human non-syndromic intellectual disability. Behav Brain Research, 226(2):428-34.

Schierberl K, Hao J, Tropea TF, Ra S, Giordano TP, Xu Q, Garraway SM, Hofmann F, Moosmang S, Striessnig J, Inturrisi CE, Rajadhyaksha AM. (2011) Ca_v1.2 L-type Ca²⁺ channels mediate cocaine-induced GluA1 trafficking in the nucleus accumbens, a long-term adaptation dependent on ventral tegmental area Ca_v1.3 channels. J Neurosci. 31(38):13562-75.

Ren JQ, Jiang Y, Wang Z, McCarthy D, Rajadhyaksha AM, Tropea TF, Kosofsky BE, Bhide PG. (2011) Prenatal L-DOPA exposure produces lasting changes in brain dopamine content, cocaine-induced dopamine release and cocaine conditioned place preference. Neuropharmacolology, 60:295-302.

Giordano TG, Tropea TF, Satpute SS, Sinnegger M, Striessnig J, Kosofsky BE, Rajadhyaksha A. (2010) Molecular switch from L-type Ca_v1.3 to Ca_v1.2 Ca² channel signaling in the nucleus accumbens underlies long-term psychostimulant-induced behavioral and molecular plasticity. J Neuroscience, 30:17051-62.

Rajadhyaksha AM, Elemento O, Puffenberger EG, Xiang JZ, Schierberl KC, Tal AL, Putorti ML, Kosofsky BE, Ra S, Berciano J, Combarros O, Brais B, Poulin C, Michaelides M, Morton DH, Hayflick S, Hogarth P, Shawn Westaway S, Higgins JJ. (2010) Mutations in FLVCR1 cause posterior column ataxia and retinitis pigmentosa. American J Human Genetics, 87:643-54.

Gregus AM, Inra CN, Giordano TP 3^rd, Costa ACS, Rajadhyaksha A, Inturrisi CE. (2010) Spinal mediators that may contribute selectively to antinociceptive tolerance but not other effects of morphine as revealed by deletion of GluR5. Neuroscience, 11:475-87.

Higgins J, Tal A, Hauck SCR, Hao J, Kosofsky BE, Rajadhyaksha A. (2010) Developmental and regional mouse brain expression of cereblon, an ionic channel regulator involved in human intelligence. J Neurogenetics, 24:18-26.

Gregus AM, Tropea TF, Wang Y, Hauck SCR, Costa ACS, Rajadhyaksha A, Inturrisi CE. (2010) Deletion of the GluR5 subunit of kainite receptors affects cocaine sensitivity and cocaine preference.& Neurosci. Letters 468:186-9.

Bogulavsky JJ, Gregus AM, Kim PT, Costa AC, Rajadhyaksha A, Inturrisi CE. (2009) Deletion of the glutamate receptor 5 subunit of kainite receptors affects the development of morphine tolerance. J Pharmacol Exp Ther, 328:579-87

Tropea TF, Kosofsky BE, Rajadhyaksha AM (2008). Enhanced CREB and DARPP-32 phosphorylation in the nucleus accumbens and CREB, ERK, and GluR1 phosphorylation in the dorsal hippocampus is associated with cocaine-conditioned place preference behavior. J. Neurochemistry, 106: 1780-90.

Higgins JJ, Hao J, Kosofsky BE, Rajadhyaksha AM (2008). Dysregulation of large conductance Ca2 -activated K channel expression in non-syndromal mental retardation due to a cereblon p.R419X mutation. Neurogenetics, 9: 219-23.

Covington, HE 3rd, Tropea TF, Rajadhyaksha AM, Kosofsky BE, Miczek KA (2007). NMDA receptors in the rat VTA: a critical site for social stress to intensify cocaine taking. Psychopharmacology, 197:203-16.

Higgins JJ, Kosofsky BE, Giordano TP, Tropea TF, Deshmukh M, Rajadhyaksha AM (2007). Functional aspects of cereblon in mild autosomal recessive nonsyndromic mental retardation. Neurology, 68 (suppl 1):A399-400.

Giordano III TP, Satpute SS, Striessnig J, Kosofsky BE, Rajadhyaksha AM (2006). Upregulation of Dopamine D2L mRNA levels in the ventral tegmental area and dorsal striatum of amphetamine-sensitized C57BL/6 mice: role of Cav1.3 L-type Ca2 channels. Journal of Neurochemistry, 99:1197-206.

Rajadhyaksha A and Kosofsky, BE. Psychostimulants, L-type calcium channels, kinases and phosphatases (2005). Neuroscientist, 11:494-502.

Rajadhyaksha A and Kosofsky, BE. Psychostimulants, Protein phosphorylation and Gene expression: a growing role of L-type calcium channels (2005). Cell Science, 2: 127-140.

Guerriero RM, Rajadhyaksha A, Crozatier C, Giros B, Nosten-Bertrand M, Kosofsky BE (2005). Augmented Constitutive CREB expression in the nucleus accumbens and striatum may contribute to the altered behavioral response to cocaine of adult mice exposed to cocaine in utero. Developmental Neuroscience, 27:235-248.

Eaton M, Macias W, Youngs RM, Rajadhyaksha A, Dudman JT, Konradi C (2004). L-type Ca2 channel blockers promote Ca2 accumulation when dopamine receptors are activated in striatal neurons. Molecular Brain Research.131: 65-72.

Rajadhyaksha A, Husson I, Satpute SS, Kuppenbender KD, Ren JQ, Guerriero RM, Standaert DG, Kosofsky, BE (2004). L-type Ca2 channels mediate adaptation of ERK1/2 phosphorylation in the ventral tegmental area after chronic amphetamine treatment. Journal of Neuroscience, 24: 7464-76.

Dudman T, Eaton M, Rajadhyaksha A, Macias W, Taher Muffadal, Barczak A, Kameyama K, Huganir Konradi, C (2003). Dopamine D1 receptors mediate CREB phosphorylation via phosphorylation of the NMDA Ser897-NR1. Journal of Neurochemistry, 87: 922-934.

Macías W, Carlson R, Rajadhyaksha A, Barczak A, Konradi C (2001). Potassium Chloride depolarization mediates CREB phosphorylation in striatal and hippocampal neurons by two different mechanisms. Brain Research, 890: 222-32.

Leveque, J-C, Macias W, Rajadhyaksha A, Carlson R, Barczak A, Kang S, Li X-M, Coyle J, Huganir R, Heckers S, Konradi C (2000). Intracellular modulation of NMDA receptor function by antipsychotic drugs. Journal of Neuroscience, 20:4011-4020.

Rajadhyaksha A, Barczak A, Macías A, Leveque J-C, Lewis S, Konradi C (1999). L-type Ca2 channels are essential for glutamate-mediated CREB phosphorylation and c-fos gene expression in striatal neurons. Journal of Neuroscience, 19:6348-6359.

Rajadhyaksha A, Leveque J-C, Macías W, Barczak A, Konradi C (1998). Molecular components of striatal plasticity: The various routes of cyclic AMP pathways. Developmental Neuroscience, 20: 204-215.

Rajadhyaksha A, Riviere M, Vanvooren P, Szpirer J, Szpirer C, Babin J, Bina, M. Assignment of AR1, transcription factor 20 (TCF20), to human chromosome 22q13.3 with somatic cell hybrids and in situ hybridization (1998). Cytogenetics and Cell Genetics, 81:176-177.

Tesmer V, Rajadhyaksha A, Babin J, Bina M. NF-IL6-mediated transcriptional Activation of the long terminal repeat of the Human Immunodeficiency Virus Type 1 (1993). Proc Natl Acad Sci USA, 90:7298-7302.

Ambrose C, Lowman H, Rajadhyaksha A, Blasquez V, Bina M. Location of nucleosomes in simian Virus 40 chromatin (1990). Journal of Molecular Biology, 214:875-884.

Ambrose C, Rajadhyaksha A, Lowman H, Bina M. Location of nucleosomes on the regulatory region of Simian Virus 40 chromatin (1989). Journal Molecular Biology, 210:255-263.