Publications
Kuraguchi, M., Edelmann, W., Yang, K., Lipkin, M., Kucherlapati, R., and Brown, A.M.C. (2000) Tumor-associated Apc mutations in Mlh1-/-Apc1638N mice reveal a mutational signature of Mlh1 deficiency. Oncogene, 19, 5755-5763.
Howe, L.R., Crawford, H., Hassell, J.A., Dannenberg, A.J., and Brown, A.M.C. (2001) PEA3 is upregulated in response to Wnt-1 and regulates the Cyclooxygenase-2 promoter. J. Biol. Chem., 276, 20108-20115.
Brown, A.M.C. (2001) Wnt signaling in breast cancer: have we come full circle? Breast Cancer Research 3, 351-355.
You, Z., Saims, D., Chen, S., Zhang, Z., Guttridge D.C., Guan, K-L., MacDougald, O.A., Brown, A.M.C., Evan, G., Kitajewski J., Wang, C-Y. (2002) Wnt signaling promotes oncogenic transformation by inhibiting c-Myc-induced apoptosis. J. Cell. Biol., 157, 429-440.
Howe, L. R., Subbaramaiah, K., Patel, J., Masferrer, J. L., Deora, A., Hudis, C., Thaler, H. T., Muller, W. J., Du, B., Brown, A. M. C., and Dannenberg, A. J. (2002) Celecoxib, a selective cyclooxygenase-2 inhibitor, protects against HER-2/neu-induced breast cancer. Cancer Res, 62, 5405-5407.
Wong, E., Yang, K., Kuraguchi, M., Werling, U., Avdievich, A., Fan, K., Fazzari, M., Jin, B., Brown, A.M.C., Lipkin, M., and Edelmann, W. (2002) Mbd4 inactivation increases C→T transition mutations and promotes gastrointestinal tumor formation. Proc. Natl. Acad. Sci. (U.S.A.), 99, 14937-14942.
Howe, L.R., Watanabe, O., Leonard, J., and Brown, A.M.C. (2003) Twist is upregulated in response to Wnt1 and inhibits mouse mammary cell differentiation. Cancer Res., 63, 1906-1913.
Anakwe, K., Robson, L., Hadley, J., Buxton, P., Church, V., Allen, S., Hartmann, C., Harfe, B., Nohno, T., Brown, A.M.C., Evans, D.J.R., and Francis-West, P. (2003) Wnt signalling regulates myogenic differentiation in the developing avian wing. Development, 130, 3503-3514.
Howe, L.R., and Brown, A.M.C. (2004) Wnt signaling and breast cancer. Cancer Biol. Ther. 3, 36-41.
Brennan, K., Gonzalez-Sancho, J.M., Castelo-Soccio, L.A., Howe, L.R., and Brown, A.M.C. (2004) Truncated mutants of the putative Wnt receptor LRP6/Arrow can stabilize β-catenin independently of Frizzled proteins. Oncogene, 23, 4873-4884.
González-Sancho, J.M., Brennan, K.R., Castelo-Soccio, L.A., and Brown, A.M.C. (2004) Wnt proteins induce Dishevelled phosphorylation via an LRP5/6-independent mechanism, irrespective of their ability to stabilize β-catenin. Mol. Cell Biol., 24, 4757-4768.
Brennan, K., and Brown, A.M.C. (2004) Wnt proteins in mammary development and cancer. J. Mamm. Gland Biol. Neoplasia, 9, 119-131.
Howe, L. R., Chang, S-H., Tolle, K.C., Dillon, R., Young, L.J.T., Cardiff, R.D., Newman, R.A., Yang, P., Thaler, H.T., Muller, W.J., Hudis, C., Brown, A.M.C., Hla, T., Subbaramaiah, K., and Dannenberg, A. J. (2005) HER2/neu-Induced mammary tumorigenesis and angiogenesis are reduced in Cyclooxygenase-2 knockout mice. Cancer Res. 65, 10113-10119.
Masckauchán, T.N., Agalliu, D., Vorontchikhina, M., Ahn, A., Parmalee, N.L., Li, C.M., Khoo, A., Tycko, B., Brown, A.M.C., and Kitajewski, J. (2006) Wnt5a signaling induces proliferation, survival, and expression of MMP-1 and Tie-2 in endothelial cells. Mol. Biol. Cell 12, 5163-5172.
Tezuka, N., Brown A.M.C., and Yanagawa, S. (2007) GRB10 binds to LRP6, the Wnt co-receptor, and inhibits canonical Wnt signaling. Biochem. Biophys. Res. Comm. 356, 648-654.
Takigawa, Y., and Brown, A.M.C. (2008) Wnt signaling in liver cancer. Current Drug Targets 9, 1013-1024.
Many, A.M., and Brown, A.M.C. (2010) Mammary stem cells and cancer: roles of Wnt signaling in plain view. Breast Cancer Res. 12, 313-315.
Gonsalves, F.C., Klein, K., Carson, B.B., Katz, S., Ekas, L.A., Evans, S., Nagourney, R., Cardozo, T., Brown, A.M.C., and DasGupta, R. (2011) An RNAi-based chemical genetic screen identifies three small-molecule inhibitors of the Wnt/wingless signaling pathway. Proc. Natl. Acad. Sci. USA, 108, 5954-5963.
González-Sancho, J.M., Greer, Y.E., Abrahams, C.L., Takigawa, Y., Baljinnyam, B., Lee, K.H., Lee, K.S., Rubin, J.S., and Brown, A.M.C. (2013) Functional conseqeunces of Wnt-induced Dishevelled 2 phosphorylation in canonical and non-canonical Wnt signaling. J. Biol. Chem., in press.
Greer, Y.E., Fields, A.P., Brown, A.M.C., and Rubin, J.S. (2013) Atypical protein kinase C iota is required for Wnt3a-dependent neurite outgrowth and binds to phosphorylated Dishevelled 2. J. Biol. Chem., in press.
