Labitzke, EM, Diani-Moore, S., and Rifkind, A.B. Mitochondial P450-dependent arachidonic acid metabolism by TCDD-induced hepatic CYP1A5; conversion of EETs to DHETs by mitochondrial soluble epoxide hydrolase. Arch. Biochem. Biophys. 2007- published on-line doi:10.1016/j.abb.2007.08.012.
Diani-Moore, S. Papachristou, F., Labitzke, E. and Rifkind, A.B. Induction of CYP1A and CYP2 mediated arachidonic acid epoxygenation and suppression of 20-HETE by imidazole derivatives including the aromatase inhibitor vorozole. Drug Metab. Disp. 34: 1376-1385, 2006.
Rifkind, A.B. CYP1A in TCDD toxicity and in physiology with particular reference to CYP dependent arachidonic acid metabolism and other endogenous substrates. Drug Metab. Rev., 38, 291-335, 2006.
Diani-Moore, S., Labitzke, E, Brown, R., Garvin, A., Wong, L and Rifkind, A.B. Sunlight generates multiple tryptophan photoproducts eliciting high efficacy CYP1A induction in chick hepatocytes and in vivo, Toxicol.. Sci. 90: 96-110, 2006.
Wood, E., Broekman, M.J., Kirley, T., Diani-Moore, S., Tickner, M., Drosopoulis, J., Islam, N., Park, J., Marcus, A., and Rifkind, A.B. Cell-type specificity of ectonucleotidase expression and upregulation by 2,3,7,8-tetrachlorodibenzo-p-dioxin. Arch. Biochem. Biophys. 407: 49-62, 2002.
Fan, L., Ovadia, M., Freidman, D.M. and , Rifkind, A.B. Ventricular preexcitation sensitive to flecainide in late stage chick embryo ECGs: 2,3,7,8-Tetrachlorodibenzo-p-dioxin impairs inotropic but not chronotropic or dromotropic responses to isoproterenol and confers resistance to flecainide. Toxicol. Appl. Pharmacol. 166: 43-50, 2000.
Gannon, M., Gilday, D. and Rifkind, A.B., TCDD induces CYP1A4 and CYP1A5 in chick liver and kidney and only CYP1A4 , an enzyme lacking arachidonic acid epoxygenase activity, in myocardium and vascular endothelium. Toxicol. Appl. Pharmacol. 164: 24-37, 1999.
Mahajan, S.S. and Rifkind, A.B. Transcriptional activation of avian CYP1A4 and CYP1A5 by 2,3,7,8 -Tetrachlorodibenzo-p-dioxin: Differences in gene expression and regulation compared to mammalian CYP1A1 and CYP1A2. Toxicol. Appl. Pharmacol. 155: 96-206, 1999.
Lee, C.A., Lawrence, B.P., Kerkvliet, N.I. and Rifkind, A.B. 2,3,7,8-Tetrachlorodibenzo-p-dioxin induction of cytochrome P450 dependent arachidonic acid metabolism in mouse liver microsomes; evidence for species specific differences in responses. Toxicol. Appl. Pharmacol. 153: 1-11, 1998.
Gilday, D., Gannon, M., Yutzey, K., Bader, D., and Rifkind, A.B. Molecular cloning and expression of two novel avian cytochrome P450 1A enzymes induced by 2,3,7,8-Tetrachlorodibenzo-p-dioxin. J. Biol. Chem. 271: 33054-33059, 1996. Other Publications
Education
M.D.,
New York University School of Medicine,
1964
B.A.,
Bryn Mawr College,
1960
Appointments
Associate Professor of Medicine Weill Cornell Medical College
Professor of Pharmacology Weill Cornell Medical College
