Infectious Diseases Research
Division Chief and Professor Bruce R. Schackman, Ph.D., has had a longstanding commitment to HIV/AIDS and hepatitis C testing and treatment research, including cost and cost-effectiveness analyses conducted alongside clinical trials and cohort studies; simulation modeling of comparative effectiveness and cost-effectiveness outcomes; and implementation science research regarding budgetary and operational barriers to implementing evidence-based medical interventions. He has also collaborated with Cornell investigators in Haiti in exploring cost-effective methods for diagnosing and treating HIV and syphilis.
Dr. Schackman has an ongoing collaboration with the Cost-Effectiveness of Preventing AIDS Complications (CEPAC) modeling group based at Massachusetts General Hospital in Boston. Working with this group, he has co-authored studies of the lifetime cost of HIV care and the cost-effectiveness of using generic antiretroviral drugs for HIV treatment in the United States; the potential risks and benefits of HIV treatment simplification and immune enhancement therapy; and the cost-effectiveness of pharmacogenetic testing to guide HIV treatment selection. Dr. Schackman has also co-authored policy analyses and reviews related to HIV testing and treatment published in The New England Journal of Medicine, Health Affairs, Public Administration Review, and Medical Decision Making.
With funding from the National Institute on Drug Abuse (NIDA), Dr. Schackman has led an economic substudy of a randomized clinical trial of on-site rapid HIV testing in drug treatment programs. In a previous study funded by NIDA, he compared patient and provider assessments of quality-of-life associated with chronic hepatitis C and its treatment. With colleagues, including Ann B. Beeder, M.D., Associate Professor of Public Health and Psychiatry, he also evaluated the outcomes of hepatitis C treatment offers to these patients.
Dr. Schackman has collaborated with the Groupe Haitien d'Etude du Sarcome de Kaposi et des Infections Opportunistes (GHESKIO) in Haiti to conduct an economic evaluation a new rapid syphilis test for pregnant women; to conduct a cost-effectiveness analysis alongside a the only published randomized trial of early versus standard HIV treatment; and to forecast lives saved by expanding HIV treatment availability in Haiti. Dr. Schackman’s co-researchers in Haiti including Jean W. Pape, M.D., founder and director of GHESKIO and Professor of Medicine, Warren D. Johnson, M.D., the B.H. Kean Professor of Tropical Medicine, and Daniel W. Fitzgerald, M.D., Associate Professor of Medicine.
Mathew S. Simon, M.D., has collaborated with researchers in the Division of Infectious Diseases to examine the public health impact of a recent outbreak of invasive meningococcal disease in New York City and to examine the cost-effectiveness of screening the blood supply for babesiosis in endemic regions. He will lead a new collaboration with the Division of Hospital Medicine to conduct economic and policy studies related to hospital infection control.
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