Clinically Isolated Syndrome

Clinically Isolated Syndrome (CIS) is the first episode of neurological symptoms with demyelination on MRI. Typical symptoms for CIS are optic neuritis, painful loss of visual acuity, patchy brainstem symptoms, such as vertigo, facial numbness or diplopia, or patchy transverse myelitis with tingling paresthesias, or heaviness in a leg or arm. CIS patients with abnormal MRI scans are at higher risk for developing clinically definite multiple sclerosis.

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