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Sudha Guttikonda (MD-PhD, 5th Year) Awarded NIMH F30 Fellowship



Sudha Guttikonda, Fifth Year MD-PhD student, has been awarded an F30 Fellowship from the NIMH for her project, “ hPSC-derived microglia for in vitro modeling of Rett Syndrome.” Rett Syndrome is a neurodevelopmental disorder affecting 1 in 10,000 female births that causes severe regression by 18 months of age. Hallmarks of Rett include an imbalance in inhibitory to excitatory synapses as well as excessive microglial pruning, but how these two pathologies are interconnected has yet to be fully explored. The proposed study aims to decipher microglial-neuronal interplay in Rett Syndrome using an iPSC-derived model containing both neurons and microglia. The multi-cell type system developed in this study can also be applied to better study other neurological diseases in vitro to permit clearer mechanistic understanding and to facilitate drug development.

Sudha is conducting her thesis research in the laboratory of Dr. Lorenz Studer at Memorial Sloan Kettering Cancer Center.





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