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Gustav Cederquist, Fifth Year MD-PhD Student, Receives NIMH/NIH Fellowship
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Gustav Cederquist, fifth Year MD-PhD student, has been awarded an F30 Fellowship from the NIMH
for his project, “Multiplex analysis of autism mutations using isogenic human pluripotent stem cells.” Autism is associated with hundreds of genetic variants. Despite the success of gene identification, there is a limited understanding of how to these variants impact brain development. Human pluripotent stem cells (hPSCs) have the unique ability to differentiate into any cell-type of the body, providing unprecedented access to human brain tissue. hPSCs can also be engineered to harbor the exact mutations found in autism patients. Thus, hPSCs are an ideal platform to study how autism mutations perturb human brain development. The proposed project will use of a novel multiplex platform to simultaneously interrogate dozens of isogenic disease lines for autism-associated developmental defects. This study aims to identify subgroups of autism mutations based on shared molecular phenotypes, which could ultimately lead to common routes for therapeutic intervention.
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