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Title: Research on the Treatment of Geriatric Depression

PI: George Alexopoulos, MD

Institution: Weill Cornell Medical College

IRB #: 1005011034

IRB Expiration Date: 05/22/2012

Study Description: The purpose of this study is to examine whether elderly depressed individuals whose depression symptoms do not respond well to therapy with medications that balance emotions (mood stabilizers) or antidepressants alone can benefit from taking a specific type of antibiotic called minocycline in addition to their antidepressant or mood stabilizer medication. Minocycline is a commonly used antibiotic medication that reduces inflammation (swelling). The investigators hope that this study will help better understand the role of inflammation in depression, and to see if decreasing inflammation can improve symptoms of depression and thinking ability for elderly adults with depression.

Involvement: Medication, EEG, Blood draw, Interviews, Questionnaires

Age: 55+ years

Eligibility: Diagnosis of depression

Commitment: 7 visits over 8 weeks

Compensation: Up to $125

Contact: Tim Clark at 914-997-4331 or 1-800-697-1902

Sponsor(s): Weill Cornell's Advanced Center for Interventions and Services Research