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Title: Research on Improving Exposure Therapy Treatment for Posttraumatic Stress Disorder (PTSD)

PI: JoAnn Difede, PhD

Institution: Weill Cornell Medical College

IRB#: 1005011047

IRB Expiration Date: 09/11/2012

Study Description: The purpose of this study is to compare two types of exposure therapy in the treatment of PTSD resulting from military service in Iraq and Afghanistan. These two treatments are prolonged imaginal exposure therapy and virtual reality (VR) exposure therapy. The study will also test whether the use of D-Cycloserine (DCS), a medication approved for the treatment of other disorders but not PTSD, combined with these treatments will improve the effectiveness of these therapies. Participants will be randomly assigned to receive 9 sessions of either virtual reality exposure therapy or prolonged imaginal exposure therapy, combined with either a low dose of DCS, or a placebo. This study examines predictors for PTSD and responses to PTSD intervention in active duty military personnel, veterans, and civilians who served in Iraq/Afghanistan.

Involvement: Receiving 9 sessions of either virtual reality (VR) exposure therapy or prolonged imaginal exposure therapy; taking an active DCS pill or a sugar pill (placebo) on days of sessions only (a total of 7 times); clinical interviews

Age: 18-70 years

Eligibility: Diagnosis of posttraumatic stress disorder (PTSD); service in the recent Iraw or Afghanistan conflicts (OIF/OEF/OND)

Commitment: An initial evaluation, 9 vists over 3 months, a 3- month follow-up visit

Compensation: Up to $350 (Active Duty is compensated through donation to charity in their name)

Contact: Brittany Mello at 212-821-0783

Sponsor(s): Department of Defense (DoD)