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Title: Help Researchers Learn More About the Effects of Antidepressants During Pregnancy

PI: Mallay Occhiogrosso, MD

Institution: Weill Cornell Medical College

IRB#: 1004010987

IRB Expiration Date: 7/10/2012

Study Description: At birth, all babies experience dramatic changes in the way their lungs work and in the blood flow to their lungs. This research is being done because currently we do not know enough about the impact, if any, that exposure to Selective Serotonin Reuptake Inhibiting (SSRI) antidepressant medication has on the blood circulation changes that happen to babies at the time of delivery. There is concern that SSRI exposure may increase the risk of a rare condition called pulmonary hypertension, which causes breathing difficulties in infants and changes in the blood pressure in their hearts and lungs. In your baby's heelsitck blood we will measure levels of two hormones to study potential differences in blood pressure in the lung circulation. An echocardiogram will also be used to measure blood pressure in the lung circulation. Lastly, we will collect measures of your baby's behavior to check for any differences among the three groups of subjects and whether these are related to SSRI exposure or blood pressure changes. This is not a treatment study; no treatment will be given to you or your baby as part of this study.

Involvement: Interview, Blood draw, Neurological exam, and Echocardiogram for newborn

Age: 18-42 years

Eligibility: Pregnant women with and without SSRI antidepressant medication

Commitment:2 visits and 3 follow-up phone calls over 2-3 months

Compensation: $25 gift card

Contact: Dr. Mallay Occhiogrosso at 212-746-3529 or

Sponsor(s): Brain and Behavior Research Foundation