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Title: Studying the Effects of Medication on Bloods Tests for Individuals with and without Lupus

PI: Doruk Erkan, MD

IRB Institution: HSS

IRB #: 10130

IRB Exp: 9/2/2012

Study Description: The purpose of this study is to determine the effects of a medication, called hydroxychloroquine (HCQ), on a new blood test in people who have antiphospholipid antibodies (aPL) in their blood. People with aPL can be at increased risk for forming blood clots. Studies have suggested that the HCQ medication may help to prevent clotting. We will perform the specialized blood test on samples from people before and after they take HCQ. If we can identify a difference in the test before and after people take the medication, this will allow us to design future studies.

Involvement: Blood draw, physical exam, interview

Age: 18-65 years

Eligibility: Individuals with Antiphospholipid Antibodies both with and without Systemic Lupus Erythematosus

Commitment: 3 visits over 12 Weeks

Contact: Dr. Alana Levine at 212-774-2935 or hcqstudy@hss.edu

Sponsor(s): Barbara Volcker Center for Women and Rheumatic Diseases, Montefiore Medical Center, National Institutes of Health via the Clinical and Translational Science Center at Weill Cornell Medical College