Multi-Institutional Program Direction
Julianne Imperato-McGinley MD, Associate Dean for Translational Research and Education, is the Director and Principal Investigator (PD) of the CTSC. Dr. Imperato-McGinley is the Abby Rockefeller Mauzé Distinguished Professor of Medicine in Endocrinology, past Program Director of the Clinical Research Center, and Chief of the Division of Endocrinology, Diabetes and Metabolism. She is a clinical and translational researcher with over 25 years of NIH funding. Her landmark paper, first published in Science in 1974, defined a previously unrecognized clinical disorder - inherited 5a-reductase deficiency. Eventually the clinical implications of her research were translated into treatment of human disease; the development of the first medical therapy (finasteride) for prostate enlargement, and subsequently, for the treatment of male-pattern baldness. Her classic studies, involving androgen physiology and its effect on the body and brain were the first to significantly challenge the widely held view that gender is socially acquired. Much of her work is included in standard textbooks of endocrinology, psychology, urology and medicine. She is an elected member of the American Association of Physicians for her contributions to clinical research. In April 2005 she was awarded the EH Ahrens Award in Clinical Research.
Dr. Imperato-McGinley also has a long history of training and mentoring students from high school to MDs in fellowship training, particularly second-year endocrine fellows in their patient-oriented research projects. She is the Program Director of the K-30 Masters Program in Clinical Investigation, a recipient of two Empire State Investigator Grants for mentoring, and is the PI on a T32 endocrine training grant. She worked with the Dean to establish a prize for excellence in clinical research and served on the Medical Student Research Awards Committee for over 10 years and as chairperson for 4 years and is Program Director of the NIH funded K30 /Masters in Clinical Investigation.
Dr. Imperato-McGinley works closely with the academic deans of the Medical College and Graduate Schools and heads of all partner institutions to ensure coordination across disciplines, schools, other institutions, and affiliated hospitals. She is a strong advocate for the program and strives to develop further core concepts that will make the program distinctive.
Coordinating Program Director
A Coordinating Program Director (CPD), Timothy Wright, PhD from HSS, assists the Program Director in this complex process. Dr. Wright is an experienced investigator with a background that complements that of the PD, allowing for comprehensive oversight of all key function areas while providing optimal assistance.
Dr. Wright is a Senior Scientist at HSS, Professor of Applied Biomechanics, Department of Orthopaedics, Weill Medical College of Cornell University, and Member, Biomedical Engineering Program, College of Engineering, Cornell University. He joined HSS in 1976 and Weill Cornell Medical College in 1978. He is a recipient of honors for excellence in research from the Hip Society and the Knee Society and earned a Kappa Delta Award from the American Academy of Orthopaedic Surgeons. A past Whitaker Fellow and a past recipient of a Research Career Development Award from NIH, Dr. Wright served as president of the Orthopaedic Research Society in 1992. He is a former consulting editor for research of the Journal of Bone and Joint Surgery and is currently editor of the Journal of Orthopaedic Research. Recently, Dr. Wright received a Director's Special Citation from the U.S. Food and Drug Administration for his work on a forum of academic, industry and agency representatives striving to improve the regulatory process for orthopedic devices.
Dr. Wright's research interests are in the design of orthopedic devices with an emphasis on the wear of polyethylene total joint components. He is also focusing on the performance of bone implant systems and the analysis of retrieved components and problems with fixation as well as the mechanical properties of bone tissue.
Among Dr. Wright's current projects are an integrated approach to understanding knee component wear combining observations on retrieved components, wear experiments on a knee joint simulator, and a numerical simulation of the simulator. The goal is to provide a direct link between the wear damage mechanisms and the stress and strain state of the material.
Also under investigation are a study of cortical bone response to load as function of magnitude, frequency and duration, and a study of trabecular bone remodeling under the influence of load and growth factors using an animal model.
The governance structure (see below) integrates the CTSC partner institutions and provides oversight of all CTSC functions. It includes an Operations Committee supported by Internal and External Advisory Committees and a Community Advisory Board. A systems approach to measuring outcomes provides additional oversight by our Tracking and Evaluation Team.